UFC 270: Ngannou vs. Gane was a mixed martial arts event produced by the Ultimate Fighting Championship that took place on January 22, 2022, at the Honda Center in Anaheim, California.

A UFC Heavyweight Championship title unification bout between current champion Francis Ngannou and interim champion Ciryl Gane served as the event headliner.

A UFC Flyweight Championship trilogy bout between current champion Brandon Moreno and former champion Deiveson Figueiredo took place at the event. The pairing first met at UFC 256 on December 12, 2020, which ended in a majority draw (Figueiredo retained the title). Their second meeting took place at UFC 263 on June 12, 2021, where Moreno captured the title by submission in the third round. The rematch was originally expected to take place at UFC 269, but it was moved to this event.

A middleweight bout between Jared Cannonier and Derek Brunson was scheduled for the event. However, the pairing was moved to UFC 271 three weeks later.

A women's flyweight bout between Kay Hansen and Jasmine Jasudavicius was scheduled for UFC on ESPN: Kattar vs. Chikadze. However, the pairing was moved to this event due to undisclosed reasons.

The Ultimate Fighter: Brazil 3 middleweight winner Warlley Alves was expected to face Jack Della Maddalena in a welterweight bout. However, Alves pulled out in early January due to undisclosed reasons and he was replaced by promotional newcomer Pete Rodriguez.

A women's flyweight between Viviane Araújo and Alexa Grasso was scheduled for the event. However, Araújo was forced to pull out from the event due to injury and the bout was cancelled.

A featherweight bout between undefeated prospects Movsar Evloev and Ilia Topuria was scheduled for the event. However, Evloev withdrew from the bout due to undisclosed reasons. He was replaced by Charles Jourdain. In turn, Topuria withdrew from the bout just before the weigh in due to a medical issue from cutting weight and the bout was scrapped.