UFC 68: The Uprising was a mixed martial arts (MMA) event held by the Ultimate Fighting Championship on March 3, 2007, at the Nationwide Arena in Columbus, Ohio.

UFC 68 was the first UFC event held in the state of Ohio, and coincided with the 2007 Arnold Sports Festival. The sold-out event produced the highest verifiable live attendance to date for a mixed martial arts event in North America with 19,079 spectators. At the time it was the largest attendance for a MMA event in the United States.

In the main event, UFC Heavyweight Champion Tim Sylvia was set to defend his title against Randy Couture, who was coming out of a 12-month retirement. Couture, a former UFC Heavyweight and Light Heavyweight Champion, hadn't fought as a heavyweight since UFC 39 in 2002.

Also featured at UFC 68 were the return bouts of former champions Matt Hughes at welterweight and Rich Franklin at middleweight.