Patrol Squadron 45 (VP-45) is a maritime patrol squadron of the United States Navy. The squadron was established on 1 November 1942 and is based at Naval Air Station Jacksonville, Florida, United States. Since 2014, VP-45 is equipped with the Boeing P-8 Poseidon aircraft.

VP-45 was established as Patrol Squadron 205 (VP-205) on 1 November 1942, redesignated Patrol Bombing Squadron 205 (VPB-205) on 1 October 1944, redesignated Patrol Squadron 205 (VP-205) on 15 May 1946, redesignated Medium Patrol Squadron (Seaplane) 5 (VP-MS-5) on 15 November 1946, and redesignated Patrol Squadron 45 (VP-45) on 1 September 1948. It is the third squadron to be designated VP-45. The first VP-45 was redesignated VP-14 on 1 December 1939 and the second VP-45 was redesignated VPB-45 on 1 October 1944.

8-1969 VP-45 took ownership of three P-2V-7 on UNITAS X. There new designations were LN-40 147951, LN-41 147062 which were in South America and spare at NAS Jax VP-45 LN-42 147959 which flew first flew 9-4

The squadron was assigned the following aircraft, effective on the dates shown:

The squadron was assigned to these home ports, effective on the dates shown:

This article incorporates text from the public domain Dictionary of American Naval Aviation Squadrons.