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VU-0152099

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VU-0152099

VU-0152099 is a positive allosteric modulator of the M4 receptor used in scientific research.

VU-0152099 is a positive allosteric modulator acting at M4 receptors, it lacks agonist activity, which means it cannot activate the receptor on its own, but can potentiate the activity of M4 receptor agonists such as acetylcholine.

In rats, VU-0152099 is able to decrease self-administration of cocaine and reverse hyperlocomotion induced by amphetamine.

These tests show that VU-0152099 could potentially be developed as a treatment for addiction to stimulants.

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