Vanessa Kirby was born in Wimbledon, London, England, on April 18, 1988. Growing up in a supportive environment with her father, a urologist, and mother, a former editor of Country Living magazine, she developed an early interest in acting. This formative period laid the foundation for her future pursuit of a career in the performing arts, fostering a love for storytelling and performance.

After being rejected from Bristol Old Vic Theatre School, Kirby took a gap year travelling before studying English at Exeter University. Despite the initial setback, she persevered in her acting ambitions. She turned down her place at LAMDA after being signed to a talent agency, paving the way for immediate professional stage work. This decision marked a pivotal moment, showcasing her determination and setting her on a path towards early recognition in theatre.