Bush began his long and impactful career at MIT as a professor of electrical engineering. He quickly became known for his innovative teaching methods and his ability to inspire students.

Bush led the development of the differential analyzer, one of the earliest analog computers. This machine was a significant advance in computational technology and was used for solving complex scientific and engineering problems. He progressively improved the initial designs, culminating in more advanced models that could handle even more intricate calculations. These advances brought him international recognition.

Bush invented the Profile Tracer, a device that automatically recorded ground profiles for topographical mapping. This invention demonstrated his practical application of engineering principles to solve real-world problems.

His work on the differential analyzer and other inventions led to his promotion to full professor at MIT, solidifying his position as a leading figure in electrical engineering.