Velika Plana (Serbian Cyrillic: Велика Плана, pronounced [ʋêlikaː plǎːna] ^ⓘ) is a town and municipality located in the Podunavlje District of Serbia. As of 2022, the town has 14,609 inhabitants, while the municipality has 35,451. Velika Plana lies on the left bank of Velika Morava.

The municipality of Velika Plana has 13 settlements. The town is composed of three townships: Town Mains, Stari Odbor (the Old Downtown), and Bresje. Town Mains is further subdivided into the neighbourhoods of Centar, Bugarija, Đurakovac, Kod Železničke (railway station area), Gloža-Ciglana (brick factory area) where a tiny Morava river village has been reconstructed, and Magareća Glava ('Donkey Head'). There is also a satellite so-called weekend settlement (vikend naselje) next to the Pokajnica monastery between Velika Plana, Staro Selo and Radovanje.

As of the 2011 census, the municipality had 40,902 inhabitants.

The ethnic composition of the municipality:

The origins of industry in Velika Plana are connected to its agricultural environment and starts in the 1880s. Before World War II, there were three slaughterhouses-meat processing plants here, first that of Italian citizen of German origin Toni Klefiš (Tony Klefisch), and later that of Germans Christian Scheuß and Wilhelm Schumacher, and the one whose stocks were owned by a group of three larger and seven smaller Serbian entrepreneurs.

After World War II, all this property was nationalised and unified into a huge plant, expanding to include all sorts of food and food-related production, all the way to clothes and duvets with goose down. These have, however, folded in the 1990s with the disastrous events concurrent with the breakup of the former Yugoslavia.

Today, the main form of industry is a branch of Goša FOM from Smederevska Palanka and the newly opened plant which produces parts for the military industry.

The following table gives a preview of total number of registered people employed in legal entities per their core activity (as of 2018):