In the video game industry, 2021 saw the release of many new titles. The numerous delays in software and hardware releases due to the continuation of the COVID-19 pandemic heavily impacted development schedules, leading to several games being delayed into 2022 or even postponed indefinitely. Additionally, computer and console hardware were impacted by the combined effects of a semiconductor shortage (partially from post-COVID-19 effects) and a rising growth of bitcoin mining that strained the supply of critical components.

According to market research firm Newzoo, the global video game market reached total revenues of US$180.3 billion, a 1.4% growth from 2020. Of this, 52% of the revenue was attributed to the mobile game market and the larger growth over the prior year, 28% to the console games market (including hardware and software), and 20% to the personal computer market.

According to market research firm Newzoo, the following countries were the largest video game markets in 2021.

The following titles are the top ten highest-grossing mobile games of 2021.

The following titles were 2021's top six highest-grossing video games in China.

The following titles were 2021's top ten best-selling premium games by region (excluding microtransactions and free-to-play titles) on PC and console platforms, for Japan, the United States, and Europe.

Metacritic is an aggregator of video game journalism reviews. It generally considers expansions and re-releases as separate entities.

The list of game-related hardware released in 2021.