Voodoo Vince is a 2003 platform video game developed by American developer Beep Industries and published by Microsoft Game Studios for the Xbox. Unlike other Xbox games, however, this game is not compatible with the Xbox 360. It was released in North America on September 23, 2003, in Europe on October 17, 2003, and in Japan on July 22, 2004. A remastered version for Microsoft Windows and Xbox One was released by Beep Games under license from Microsoft on April 18, 2017.

In the game, the player controls Vince, a voodoo doll who can perform an assortment of moves to make his way through the levels. Vince can perform standard moves such as jumps, punches, and a spin attack. The game revolves around Vince's ability to use voodoo powers, which the player can get by finding special voodoo icons scattered through the game. When Vince's voodoo power meter is full, the player can use a voodoo power to destroy every enemy nearby. Each voodoo power uniquely hurts Vince, but they all have roughly the same effect on Vince's enemies.

Scattered throughout the game's levels are special items for Vince to collect: Zombie Dust Bags, which upon collecting 100 will increase Vince's health bar; Hearts, which give Vince extra lives; Beads, which are collected from fallen enemies and fill Vince's voodoo power meter; and Skull Pages, which upon collecting all in a certain level will reveal a Skull. If the player manages to find, chase, and capture the Skull, it will increase the number of voodoo powers Vince can perform at one time. Many levels also offer a trolley station, which allows the player to travel between different levels of the game.

Many of the game's levels have some sort of puzzle in which Vince must activate some sort of device to use it to inflict pain on himself to destroy a larger enemy (the bosses in particular). For instance, in one of the first levels of the game, Vince must defeat a pair of unruly gas pumps, by setting himself on fire and then throwing himself in a puddle of gasoline surrounding the gas pumps.

Several levels differ from the standard gameplay the player experiences through the rest of the game and involve piloting a vehicle or playing a minigame. Over the course of the game, the player controls Vince piloting an airplane, a swamp boat, a submarine, a bumper car, and other vehicles.

The story of Voodoo Vince is told through the course of the game and the game manual, which reveals the names of some of the characters in the game and has bios of the game's main characters.

The game opens with Jeb and Fingers breaking into Madam Charmaine's voodoo shop to steal her Zombie Dust. In their attempt, they accidentally release the powers of the Zombie Dust, causing chaos in the shop. In the confusion, a stray bit of Zombie Dust hits Vince, bringing him to life. Madam Charmaine enters the room and attempts to stop the ruckus, but is hit by a flying object and is knocked unconscious. Jeb and Fingers then tie up Madam Charmaine and take her and her Zombie Dust to their boss, Kosmo the Inscrutable. Already, the escaped Zombie Dust starts to bend and warp reality due to Jeb and Fingers' less than careful handling.

Back in the voodoo shop, Vince is given life as a result of the zombie dust's power. After a telepathic communication from Madam Charmaine, Vince leaves to rescue her. Vince travels through the French Quarter of New Orleans, where he defeats a few enemies in his way such as a sleepy "Piggy Bank of Doom" and Reggie and Primo, two unruly gas pumps. In the square, Bones McMurty, a skeleton jazz musician, tells Vince that he can find many answers in a nearby museum, but that he will only let him in if Vince plays a song with him. After exploring some of the shops in the square and producing a trumpet, Vince does a duet with the skeleton, who lets him into the museum. Inside, the floating head of Kosmo causes a dinosaur skeleton named "The Bone Goliath" to come to life and attack Vince. Using his voodoo powers, Vince defeats the dinosaur and discovers a hidden tunnel beneath its feet.