Hadhramaut (Arabic: حَضْرَمَوْت, romanized: Ḥaḍramawt pronunciation^ⓘ; Hadrami Arabic: حَضْرَمُوت, romanized: Ḥaḍramūt pronunciation^ⓘ) is a geographic region in the southern part of the Arabian Peninsula which includes the Yemeni governorates of Hadhramaut, Shabwah and Mahrah, Dhofar in southwestern Oman, and Sharurah in the Najran Province of Saudi Arabia, and sometimes the Aden, Abyan and Lahij governorates of Yemen at a more stretched historical definition. The region's people are known as the Hadharem. They formerly spoke Hadramautic, an old South Arabian language, but they now predominantly speak the Hadhrami dialect of Arabic.

Though the origins of the name are unknown, the name Hadhramaut is traditionally explained as a compound word meaning "death has come" or "court of death," derived either from the Arabic ḥaḍara ("he came") plus mawt ("death"), a folk nickname for Amer bin Qahtan, the region's legendary first settler, or from the Biblical Hebrew ḥaṣar ("court" or "dwelling") plus māweṯ ("death") as seen in Hazarmaveth. The name is of ancient origin and is reflected in the name of the modern-day Yemeni governorate of Hadhramaut.

The boundaries of Hadhramaut stretches from the Empty Quarter desert in the north down through its Wadi Hadhramaut and its coastal plain on the Arabian Sea, historically spanning from modern-day Aden in the west across Dhofar to the east but today spans Yemen's Shabwah from the west and Oman's Dhofar to the east. The region once comprised the Qu'aiti and Kathiri sultanates whose lands now form the Hadhramaut governorate, with tribal Hadhrami towns clustered around oasis wells in the wadis, where they farm wheat, millet, dates, coconuts and coffee, while Bedouin herders graze flocks on the plateau. Physically, the region divides into Inner Hadhramaut,centered on the main wadi and its tributaries, and Coastal Hadhramaut, a narrow plain backed by the steep Jowl escarpment rising to about 1,370 m; to the north the highland plateau (Haḍbat Ḥaḍramawt) slopes down sharply into the Empty Quarter, creating a transition from lush valley to arid desert.

The origins of the name Ḥaḍramawt is disputed, and numerous debated hypotheses regarding its meaning exist. The most popular folk etymology is that the word comes from a nickname of Amer bin Qahtan, who is thought to be the first person to dwell in the region, meaning "death has come", from the words in Arabic: حَضَر, romanized: ḥaḍara, lit. 'he came' and Arabic: مَوْت, romanized: mawt, lit. 'death'. Another theory is that it is a variant of the name of Islamic prophet Hud who was sent to this region or his last words "Ludara al-mawt," meaning "death has come."

The name Ḥaḍramawt has also been found within Biblical Hazarmaveth. The name means "court of death" and is composed of two parts: Hebrew: חֲצַרְ, romanized: ḥaṣar, lit. 'dwelling; court' and Hebrew: מָוֶת māweṯ "death". There, Hud was the descendant of ʿĀd, son of Joktan, the purported ancestor and progenitor of the South Arabian kingdoms. According to tradition, the family of ʿĀd was the first to settle in the region, and when the sons of ʿĀd had died, Amer bin Qahtan, nicknamed "Hadhramaut", came to power.

Though the origins of the name are unknown, there are several scholarly proposals. Kamal Salibi says that the diphthong "-aw" is an incorrect vocalisation, noting that "-ūt" is a frequent ending for place names in the Ḥaḍramawt; given that "Ḥaḍramūt" is the colloquial pronunciation of the name, and also its ancient pronunciation, the correct reading of the name would thus be "place of ḥḍrm". Salibi proposes, then, that the name means "the green place", which is appropriate given its well-irrigated wadis, giving a lushness that contrasts with the surrounding high desert plateau.

Variations of the name are attested to as early as the middle of the 1st millennium BC. The names ḥḍrmt (𐩢𐩳𐩧𐩣𐩩) and ḥḍrmwt (𐩢𐩳𐩧𐩣𐩥𐩩) are found in texts of the Old South Arabian languages (Ḥaḍramitic, Minaic, Qatabanic and Sabaic), though the second form is not found in any known Ḥaḍramitic inscriptions. In either form, the word itself can be a toponym, a tribal name, or the name of the kingdom of Ḥaḍramawt. In the late fourth or early 3rd century BC, Theophrastus gives the name Άδρραμύτα, a direct transcription of the Semitic name into Greek.

The earliest human activities in the region date from the Middle Palaeolithic, with the local population using a Levallois technique for flake preparation until the appearance of tools produced by a desert-dwelling pre-agricultural population. From this latter period, or perhaps the succeeding one, can be dated several megalithic structures, large stone circles, and four dolmen-like strictures whose inner surfaces were decorated with repetitive rows of pecked meander or crenellated design.