Wales is a town in Erie County, New York, United States. The town is one of the "Southtowns" of Erie County by virtue of its position in the southeast part of the county, southeast of Buffalo. As of the 2020 census the town had a population of 3,009. It is part of the Buffalo-Niagara Falls metropolitan area.

The town was formed in 1818 from the town of Willink.

Originally a farming community, the town of Wales is documented through profiles of its churches, civic organizations, businesses, and individual citizens. Established in 1818, the town of 3,000 residents is located in a scenic area of Erie County amid woodlands and streams. Town boards over the years have been respectful of the residents' desire to maintain a small-town atmosphere and quality of life, and the transition to modern life has emphasized small, family-oriented businesses. Personal commitment and a spirit of volunteerism have prevailed in the community, as evidenced by its many interactive organizations.

The town is named because its hills and green fields reminded settlers of the nation of Wales.

According to the United States Census Bureau, the town has a total area of 35.6 square miles (92.3 km²), of which 35.6 square miles (92.2 km²) is land and 0.04 square miles (0.1 km²), or 0.14%, is water.

The east town line is the border of Wyoming County.

New York State Route 400 begins in South Wales near the southwest part of the town. Route 20A is an east-west road in the town. Route 16 is a north-south road in the southwest part of town. New York State Route 78 is an east-west road in the center of town.

The East Branch of Cazenovia Creek flows northward in the southwest corner of town.