Waterproof is a village in Tensas Parish in northeastern Louisiana, United States with a population of 541 as of the 2020 census. In 2010, 91.7 percent of the village population was African American. Some 24 percent of Waterproof residents in 2010 were aged sixty or above.

Waterproof is approximately 17 mi (27 km) north of Ferriday, one of the two principal communities of Concordia Parish. The village is named for its relative safety from flooding prior to construction of the Mississippi River levee system.

With a population dependent on agriculture, the rural village struggles with poverty. Mechanization has decreased the need for farm labor. Industrial-scale cotton is the major commodity crop, but corn and soybeans are also important.

Jim Crow rules were strong through the segregation era, and the Ku Klux Klan was active in southwest Louisiana through the late 20th century. Although there were 7,000 blacks living in the parish in 1964, none had been registered to vote. The 4,000 whites controlled parish and city politics for decades. The first 15 blacks were registered to vote in 1964, after passage of national civil rights legislation.

Three young Waterproof men died in action in the Vietnam War: Carl Raymond Goodfellow, a navy ensign; Robert Lee Ross, an army private; and Douglas Mac Washington, an army sergeant.

As of 1990, Waterproof hosted "a general store, a grocery, two gas stations, two banks and the Western Auto franchise".

The village has the Tensas Parish Detention Center South. This prison facility holds inmates sentenced in Waterproof and Tensas Parish courts and courts of other cities in the Tensas Parish area. It has recently been used to detain undocumented immigrants. The listed address of Tensas Parish Detention Center South is 8606 Highway 65.

On December 8, 2018, the village elected its youngest mayor in history, Jarrod Randell Bottley, an African American male. He was 31 years old at the time and serves the town on a full-time basis.