The Wayans Bros. is an American sitcom television series that aired on The WB from January 11, 1995, to May 20, 1999. The series starred real life brothers Shawn and Marlon Wayans, comedian John Witherspoon, and Anna Maria Horsford (season 2 onward).

Shawn and Marlon Williams (Shawn Wayans and Marlon Wayans) are brothers who live in an apartment on 117th Street in Harlem. Shawn owns a local newsstand, where he and his brother Marlon work on a daily basis. Their father, John "Pops" Williams (John Witherspoon), owns a diner called Pops' Joint, where Marlon once worked (during season 1). Formerly located in Harlem, the restaurant was later moved downtown into the fictional Neidermeyer Building, in Rockefeller Center, where Shawn's newsstand is located and Dee Baxter (Anna Maria Horsford (onwards from Season 2)) works as a security guard.

The Wayans Bros. was the first of the four sitcoms that aired as part of the original Wednesday night two hour lineup that helped launch the network (along with Unhappily Ever After, The Parent 'Hood, and the short-lived Muscle). While in development, the series' working title was initially supposed to have been Brother to Brother before the name of the series changed to The Wayans Bros.

In the show's second season in 1995, Pops' Joint (the restaurant owned by Shawn and Marlon's father, John "Pops" Williams) was moved into the Neidermeyer Building where the location was changed from Harlem to Rockefeller Center, Manhattan.

While the series did not end on a cliffhanger, it was cancelled in 1999 due to declining ratings and was not given a proper finale. In the horror comedy film Scary Movie (2000), Shawn Wayans' character, while furiously stabbing another character to death, breaks the fourth wall and says: "And The Wayans Bros. was a good show, man! It was a good-ass show, and we didn't even get a final episode!"

The show's official opening title began with Shawn and Marlon on the steps of a brownstone apartment building, donning afros and wearing 1970s preppy attire, moving in rhythm to an accompanying satirical music piece that's supposed to have a 1970s-style "urban" sitcom theme song feel. Marlon forcefully smacks the camera, and then segues into "the real opening" of The Wayans Bros.

The scene then cuts to them with their normal clothes and trying to help an old woman who gets hit by a bus. The camera then shows the brothers inside the bus with the title of the show underneath them. The "second half" part of The Wayans Bros. theme song was changed twice throughout its four-year run (1995–1999). In the first two seasons, the show's theme song was A Tribe Called Quest's "Electric Relaxation".

In the third season, the theme song changed to a four-second hip hop beat. In the final two seasons, the show's theme song was changed again to a regular hip hop instrumental beat (which was produced by the Wayans Bros. & Omar Epps). In Brazilian reruns of seasons one and two episodes that have aired in SBT in 2015, this version replaced the seasons one and two sequence with the season three sequence.