Will & Grace is an American television sitcom created by Max Mutchnick and David Kohan. Set in New York City, the show focuses on the friendship between best friends Will Truman (Eric McCormack), a gay lawyer, and Grace Adler (Debra Messing), a straight interior designer. The show was originally broadcast on NBC from September 21, 1998, to May 18, 2006, for a total of eight seasons, before returning to NBC on September 28, 2017, and permanently ending on April 23, 2020. Will & Grace has been one of the most successful television series with gay principal characters.

Despite initial criticism for its stereotypical portrayal of gay characters, it went on to become a staple of NBC's Must See TV Thursday night lineup and was met with continued critical acclaim. It was ensconced in the Nielsen top 20 for half of its 1998–2006 network run. The show was the highest-rated sitcom among adults 18–49 from 2001 to 2005. Will & Grace earned 18 Primetime Emmy Awards and 96 nominations. Each main actor received an Emmy Award throughout the series. In 2014, the Writers Guild of America placed the sitcom at number 94 in their list of the 101 best-written TV series of all time.

Since the final episode of the 1998–2006 run aired, the sitcom has been credited with helping and improving public opinion of the LGBT community, with then U.S. Vice President Joe Biden commenting that the show "probably did more to educate the American public" on LGBT issues "than almost anything anybody has ever done so far". In 2014, the Smithsonian Institution added an LGBT history collection to their museum which included items from Will & Grace. Curator Dwight Blocker Bowers stated that the sitcom used "comedy to familiarize a mainstream audience with gay culture" in a way that was "daring and broke ground" in American media.

During its original run, Will & Grace was filmed in front of a live studio audience (most episodes and scenes) on Tuesday nights, at Stage 17 in CBS Studio Center. A long-running legal battle between both the original executive producers and creators and NBC took place between 2003 and 2007. Will and Grace's apartment was put on display at the Emerson College Library, donated by series creator Max Mutchnick. When the set was removed in 2014, rumors came up about a cast reunion, but the actors involved denied that such a reunion was planned, explaining it was merely being moved.

In September 2016, the cast reunited for a 10-minute special (released online), urging Americans to vote in the 2016 presidential election. After its success, NBC announced that the network was exploring the idea of putting Will & Grace back into production. In January 2017, NBC confirmed the series' return for a ninth season, for the 2017–2018 television season, which was eventually expanded to 16 episodes. This was followed by renewals for 18-episode tenth and eleventh seasons. On July 25, 2019, it was announced that the eleventh season would be the final season of the series which premiered on October 24, 2019, and concluded on April 23, 2020.

Will & Grace is set in New York City and focuses on the relationship between Will Truman, a gay lawyer, and his best friend Grace Adler, a Jewish woman who owns an interior design firm. Alongside them are their friends Karen Walker, a demonically alcoholic socialite, and Jack McFarland, a gay actor. The interplay of relationships features the trials and tribulations of dating, marriage, divorce, and casual sex; as well as comical key stereotypes of gay and Jewish culture.

Creators of Will & Grace and real-life friends Max Mutchnick and David Kohan modeled the show after Mutchnick's relationship with childhood friend Janet Eisenberg, a New York City voice-over casting agent. Mutchnick, who is gay, met Eisenberg while rehearsing a play at Temple Emanuel in Beverly Hills, California, when aged 13. He was the main star of the Hebrew school musical, while she was a student in the drama department. About three years later, she introduced him to Kohan, the son of comedy writer Alan Kohan, in the drama department at Beverly Hills High School. "Max and Janet seemed to have a lovely rapport, but the romantic element confused me, and it confused them as well", Kohan later recalled. "They went out for a couple of years, then they went off to different colleges. And Max comes out of the closet, springs it on her—and she was stunned. It was a shocking revelation for her, so I kind of functioned as a liaison between the two of them, because they both still really loved each other."

While Kohan practiced his shuttle diplomacy, he and Mutchnick began developing sitcom ideas, which prompted the pair to start writing as a duo. They eventually landed staff jobs on HBO's adult-themed sitcom Dream On and executive produced the NBC sitcom Boston Common. In 1997, they developed an ensemble comedy about six friends, two of them based on Mutchnick and Eisenberg. At the same time, Warren Littlefield, the then-president of NBC Entertainment, was seeking another relationship comedy for the network as Mad About You was going off the air. When Kohan and Mutchnick pitched their idea, which centered on three couples, one of which was a gay man living with a straight woman, Littlefield was not excited about the first two couples, but wanted to learn more about the gay and straight couple, so Mutchnick and Kohan were sent to create a pilot script centering on those two characters. While Kohan and Mutchnick elaborated on the pilot script, they spent four tense months faxing Littlefield the box office grosses from hit films with gay characters such as The Birdcage and My Best Friend's Wedding.