Will Setterfield (born 5 February 1998) is a professional Australian rules footballer who plays for the Essendon Football Club in the Australian Football League (AFL). He was drafted by Greater Western Sydney with their second selection and fifth overall in the 2016 national draft, and was considered by the media to be one of the most complete midfielders in his draft year. He made his debut in the 19-point loss to Richmond at the Melbourne Cricket Ground in round 18 of the 2017 season. Setterfield also played for Carlton between 2019 and 2022.

Setterfield grew up in Albury before taking up a boarding scholarship at Caulfield Grammar School in Melbourne. He played junior football for Albury Tigers.

At the conclusion of the 2018 AFL season, Setterfield requested a trade from GWS. Essendon and Carlton were considered to be front runners in obtaining his signature. Despite being an Essendon supporter as a child, Setterfield nominated the Carlton Football Club as his preferred home. He was traded on 12 October. Widely considered a bargain coup for Carlton, former player and assistant coach Matthew Lappin tweeted "Blues fans, get excited. I coached against Setterfield in his first NEAFL game and he is a serious player, on the way to the 'Baggers". Setterfield made his Carlton debut in the Round 1 match against Richmond at the MCG. He impressed, gathering an impressive 24 disposals in what was his first AFL game after his ACL injury in 2018.

After playing only 13 games in Carlton's promising 2022 season, Setterfield was traded to Essendon in that year's trade period.

Setterfield is cousins with Greater Western Sydney AFLW player Isabel Huntington.

Updated to the end of the 2025 season.

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