Within the Supernatural fandom, Wincest is the name for the hypothetical romantic pairing, or "ship", between the brothers Sam and Dean Winchester. It is one of the most common pairings on Archive of Our Own and one of the most popular pairings in the fandom. The actors playing the brothers, Jensen Ackles and Jared Padalecki, are also sometimes shipped together. The show itself has referred to Wincest, with an in-universe fictional work about the brothers which has its own Wincest fans that appear on screen, notably in the episodes "The Monster at the End of This Book" and "Fan Fiction".

Supernatural is an American TV series following the brothers Sam (played by Jared Padalecki) and Dean Winchester (played by Jensen Ackles), who hunt supernatural beings. The show, created by Eric Kripke, Bob Singer and Kim Manners began airing in 2005 and ran for 15 seasons until the final episode in 2020.

The show centers on the sibling relationship between the brothers, and showrunner Sera Gamble once referred to the show as "the epic love story of Sam and Dean".

Sam: (With a repulsed expression) As in… Sam-slash-Dean. Together.

Dean: Like… together, together?

Sam: Yeah.

Dean: They do know we're brothers, right?

Sam: Doesn't seem to matter.