X-Men: Grand Design is an American comic book series by Ed Piskor featuring the X-Men and published by Marvel Comics in 2018–2019. The series — composed of three 2-issue limited series — abridges and condenses four decades of X-Men-related canon from 1963 to the late 1980s.

Piskor wrote, drew, colored, and lettered X-Men: Grand Design, which was described as the first superhero comic by a single creator that Marvel had published since Rick Veitch's The One in 1985–1986.

Piskor, whose previous published comics were in the alternative comics vein, described the project as an "adaptation" and as a "remix". As the series was described in Bleeding Cool, Piskor's goal was to tell "the story of the X-Men as if it were all planned out from the beginning. Each chapter condenses a decade of X-Men adventures into a single comic....".

As a child, Piskor drew "hundreds of pages" of X-Men stories. With X-Men: Grand Design, he "tasked himself with piecing together a cohesive narrative from a series created by dozens of artists and writers over the course of decades". The series was originally shepherded by Marvel editor-in-chief Axel Alonso, "who let the cartoonist retell one of the most beloved and longest-lived superhero series through the filter of alternative comics". Alonso left Marvel, however, before the series was published.

X-Men: Grand Design was published as three separate two-issue limited series in 2018 and 2019:

Individual issues included "Additional Reading" sections by Daron Jensen and Jeph York that functioned as bibliographies.

All six issues were collected in 2020 and published by Marvel as Marvel Omnibus: X-Men: Grand Design (ISBN 978-1302925246). The series was collected again in 2023 as X-Men: Grand Design Trilogy (ISBN 978-1-302-95724-7). The second collection was translated and published in France (Panini France) and Brazil (Panini Brasil).

In general, the plot of X-Men: Grand Design follows that of the original X-Men comics, as written primarily by Stan Lee and then Chris Claremont.