Edward R. Piskor Jr. (/ˈpɪskər/; July 28, 1982 – April 1, 2024) was an American alternative comics cartoonist. Piskor was known primarily for his work on Hip Hop Family Tree, X-Men: Grand Design, and the Red Room trilogy. Piskor also co-hosted the YouTube channel Cartoonist Kayfabe with fellow Pittsburgh native cartoonist Jim Rugg. In March 2024, Piskor was accused via social media of sexual misconduct. Piskor died on April 1, 2024, at the age of 41, hours after posting a suicide note via social media, defending himself against the allegations leveled against him.

Edward Piskor was born in Homestead, Pennsylvania, on July 28, 1982. He was fascinated by comics throughout his childhood. He was a great fan of mainstream comics such as The Amazing Spider-Man, but his interest in alternative comics developed rapidly when, at the age of 9, he saw a documentary that featured Harvey Pekar reading one of his American Splendor stories. Important influences included Harvey Kurtzman, Will Eisner, Jack Kirby, Robert Crumb, Daniel Clowes, Chris Ware, Kim Deitch, Gilbert Shelton, and Frank Miller.

After finishing high school, Piskor attended The Kubert School for a year, which he characterized as a mixed experience. Returning to Pittsburgh, Piskor established contact with other local area cartoonists, including Jim Rugg, Paulette Poullet, Pat Lewis, Tom Scioli, and Mark Zingarelli.

In 2003, Piskor started collaborating with Jay Lynch on comics for Mineshaft, while working on his own minicomic Deviant Funnies, first published in 2004. In addition, Piskor's autobiographical minicomic Isolation Chamber was published in 2004–2005.

During this period, Piskor began working with Harvey Pekar, his first major task being illustrating stories of American Splendor: Our Movie Year (2004), which elaborates Pekar's experience after the release of the American Splendor movie. Piskor also illustrated Pekar's graphic novel Macedonia, about "a young female student that travels from the USA to Macedonia in order to try and understand how the country has survived the break-up of Yugoslavia without spiraling into civil war as its neighboring nations did." Macedonia was released in 2007 through Villard Books. Piskor further worked with Pekar on The Beats: A Graphic History, published in 2009.

From 2008 to 2011, Piskor published Wizzywig, his own comic book series about a prodigy who becomes fascinated with social engineering, phone phreaking, and eventually computer hacking. The collected Wizzywig was published by Top Shelf Productions in 2012.

Piskor's Eisner Award-winning series Hip Hop Family Tree is a historical account of hip hop culture and the artists that have shaped the genre. The project began in January 2012, serialized by Piskor on the website Boing Boing as a one-page "semi-regular ongoing feature," running, mostly weekly, until December 2015. Hip Hop Family Tree was collected and published by Fantagraphics in four books from 2013 to 2021.

From 2017 to 2019, Piskor wrote and illustrated X-Men: Grand Design, a three-volume series focusing on the history of the X-Men, for Marvel Comics.