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Xin Lu
Xin Lu FRS is a professor of Cancer Biology and Director of the Ludwig Institute for Cancer Research at the University of Oxford. She is known for her discovery of and research on the ASPP family of proteins.
Xin Lu completed her undergraduate education in Biochemistry at Sichuan University in 1982 and her master's degree in Cell and Molecular Biology at the Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences in 1985. She moved to University College London (UCL) to complete her PhD studies supervised by Birgit Lane, and published her thesis A study of intermediate filament formation using retrovirus-mediated gene transfer in 1991.
In 1993, after a short postdoc with David Lane at Dundee University, she joined the Ludwig Institute for Cancer Research (LICR), which was based at St Mary's Hospital, Imperial College London and set up her own research group. In 2004 Lu was appointed Director of Research at Ludwig Institute for Cancer Research London Branch, and Professor of Cancer Biology at University College London. In 2007 she moved the institute to Oxford.
Lu, X (1993). "Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?". Cell. 75 (4): 765–778. doi:10.1016/0092-8674(93)90496-d. PMID 8242748.
Hsieh, Jung-Kuang; Chan, Florence S.G; O’Connor, Daniel J; Mittnacht, Sibylle; Zhong, Shan; Lu, Xin (1999). "RB Regulates the Stability and the Apoptotic Function of p53 via MDM2". Molecular Cell. 3 (2): 181–193. doi:10.1016/s1097-2765(00)80309-3. PMID 10078201.
Samuels-Lev, Yardena; O'Connor, Daniel J.; Bergamaschi, Daniele; Trigiante, Giuseppe; Hsieh, Jung-Kuang; Zhong, Shan; Campargue, Isabelle; Naumovski, Louie; Crook, Tim (2001). "ASPP Proteins Specifically Stimulate the Apoptotic Function of p53". Molecular Cell. 8 (4): 781–794. doi:10.1016/s1097-2765(01)00367-7. PMID 11684014.
Lu, Min; Zak, Jaroslav; Chen, Shuo; Sanchez-Pulido, Luis; Severson, David T.; Endicott, Jane; Ponting, Chris P.; Schofield, Christopher J.; Lu, Xin (2014). "A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway". Cell. 157 (5): 1130–1145. doi:10.1016/j.cell.2014.05.006. PMID 24855949.
Bergamaschi, Daniele; Samuels, Yardena; O'Neil, Nigel J.; Trigiante, Giuseppe; Crook, Tim; Hsieh, Jung-Kuang; O'Connor, Daniel J.; Zhong, Shan; Campargue, Isabelle (2003). "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human". Nature Genetics. 33 (2): 162–167. doi:10.1038/ng1070. ISSN 1546-1718. PMID 12524540. S2CID 22841392.
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Xin Lu
Xin Lu FRS is a professor of Cancer Biology and Director of the Ludwig Institute for Cancer Research at the University of Oxford. She is known for her discovery of and research on the ASPP family of proteins.
Xin Lu completed her undergraduate education in Biochemistry at Sichuan University in 1982 and her master's degree in Cell and Molecular Biology at the Cancer Institute, Peking Union Medical College & Chinese Academy of Medical Sciences in 1985. She moved to University College London (UCL) to complete her PhD studies supervised by Birgit Lane, and published her thesis A study of intermediate filament formation using retrovirus-mediated gene transfer in 1991.
In 1993, after a short postdoc with David Lane at Dundee University, she joined the Ludwig Institute for Cancer Research (LICR), which was based at St Mary's Hospital, Imperial College London and set up her own research group. In 2004 Lu was appointed Director of Research at Ludwig Institute for Cancer Research London Branch, and Professor of Cancer Biology at University College London. In 2007 she moved the institute to Oxford.
Lu, X (1993). "Differential induction of transcriptionally active p53 following UV or lonizing radiation: Defects in chromosome instability syndromes?". Cell. 75 (4): 765–778. doi:10.1016/0092-8674(93)90496-d. PMID 8242748.
Hsieh, Jung-Kuang; Chan, Florence S.G; O’Connor, Daniel J; Mittnacht, Sibylle; Zhong, Shan; Lu, Xin (1999). "RB Regulates the Stability and the Apoptotic Function of p53 via MDM2". Molecular Cell. 3 (2): 181–193. doi:10.1016/s1097-2765(00)80309-3. PMID 10078201.
Samuels-Lev, Yardena; O'Connor, Daniel J.; Bergamaschi, Daniele; Trigiante, Giuseppe; Hsieh, Jung-Kuang; Zhong, Shan; Campargue, Isabelle; Naumovski, Louie; Crook, Tim (2001). "ASPP Proteins Specifically Stimulate the Apoptotic Function of p53". Molecular Cell. 8 (4): 781–794. doi:10.1016/s1097-2765(01)00367-7. PMID 11684014.
Lu, Min; Zak, Jaroslav; Chen, Shuo; Sanchez-Pulido, Luis; Severson, David T.; Endicott, Jane; Ponting, Chris P.; Schofield, Christopher J.; Lu, Xin (2014). "A Code for RanGDP Binding in Ankyrin Repeats Defines a Nuclear Import Pathway". Cell. 157 (5): 1130–1145. doi:10.1016/j.cell.2014.05.006. PMID 24855949.
Bergamaschi, Daniele; Samuels, Yardena; O'Neil, Nigel J.; Trigiante, Giuseppe; Crook, Tim; Hsieh, Jung-Kuang; O'Connor, Daniel J.; Zhong, Shan; Campargue, Isabelle (2003). "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human". Nature Genetics. 33 (2): 162–167. doi:10.1038/ng1070. ISSN 1546-1718. PMID 12524540. S2CID 22841392.