Yale-NUS College was a liberal arts college in Singapore. Established in 2011 as a collaboration between Yale University and the National University of Singapore, it was the first liberal arts college in Singapore and one of the first few in Asia. With an average acceptance rate of 5.2%, it was among the most selective institutions in the world. Yale-NUS was the first institution outside New Haven, Connecticut that Yale University had developed in its 300-year history, making Yale one of the first American Ivy League schools to establish a college bearing its name in Asia.

Yale-NUS was a four-year, fully residential undergraduate institution. The first class, the class of 2017, consisted of 157 students entering in 2013. At full capacity, the college had 250 students in each class. Students would select their majors at the end of their second year, after two years of the Yale-NUS Common Curriculum. Students graduated with a Bachelor of Arts degree with Honours or a Bachelor of Science degree with Honours from Yale-NUS College, conferred by NUS.

In August 2021, it was announced that Yale-NUS College would be merged with the NUS University Scholars Programme to form a new interdisciplinary honours college, with the Class of 2025 being the last cohort of Yale-NUS students. According to Pericles Lewis, this decision was part of NUS' plan for a "broader restructuring of Singapore’s educational offerings, one that had been conceived of in 2018". The new college will not feature liberal arts subjects in its core curriculum. In January 2022, it was announced that the provisionally-named New College would be named NUS College.

The Yale-NUS Class of 2025 was the final cohort of Yale-NUS students. The College was officially closed on 30 June 2025.

Under the presidency of Richard Levin, Yale began developing a "internationalization" strategy that included expanding financial resources for international students and study abroad programs, founding the Yale World Fellows and the Center for the Study of Globalization, and joining the International Alliance of Research Universities. Administrators at Yale began considering international campus expansion in 2006, and initially approached the United Arab Emirates about establishing an arts institute on Abu Dhabi's Saadiyat Island, developed in collaboration with the university's arts professional schools. After Yale indicated that it was not willing to offer Yale degree programs at the proposed institute, the project was dropped.

Levin and National University of Singapore President Tan Chorh Chuan discussed the concept of a joint liberal arts college at the 2009 World Economic Forum in Davos, Switzerland, and eighteen months later, Levin and Yale Provost Peter Salovey circulated to the Yale faculty a prospectus for a liberal arts college in Singapore. Among the given reasons for the initiative were "develop[ing] a novel curriculum spanning Western and Asian cultures" and better preparing students for "an interconnected, interdependent global environment".

Yale-NUS College was officially launched in April 2011. In July 2012, the college held its ground-breaking ceremony; it enrolled its first class of students in 2013. Yale-NUS inaugurated its campus on 12 October 2015. The event was attended by Singaporean Prime Minister Lee Hsien Loong, Acting Education Minister (Higher Education) Ong Ye Kung and the presidents of Yale and the National University of Singapore. The college held its inaugural graduation ceremony on 29 May 2017. The certificates were presented by Tony Tan, President of Singapore, and Richard Levin, former president of Yale and chief executive of Coursera, was the guest speaker.

In 2012, Yale-NUS published its policy on academic freedom and non-discrimination, which states that “the College upholds the principles of academic freedom and open inquiry, essential core values in higher education of the highest calibre. Faculty and students in the College will be free to conduct scholarship and research and publish the results, and to teach in the classroom and express themselves on campus, bearing in mind the need to act in accordance with accepted scholarly and professional standards and the regulations of the College.” The college is also “committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities.”