The Yorùbá religion (Yoruba: Ìṣẹ̀ṣe [ìʃɛ̀ʃē]), West African Orisa (Òrìṣà [òɾìʃà]), or Isese (Ìṣẹ̀ṣe), comprises the traditional religious and spiritual concepts and practice of the Yoruba people. Its homeland is in present-day Southwestern Nigeria and Southern Benin, which comprises the majority of the states of; Oyo, Ogun, Osun, Ondo, Ekiti, Kwara, Lagos and parts of Kogi in Nigeria, the Departments of; Collines, Oueme, Plateau in Benin, and the adjoining parts of central Togo, commonly known as Yorubaland (Yoruba: Ilẹ̀ Káàárọ̀-Oòjíire). It has become the largest indigenous African tradition / belief system in the world with several million adherents worldwide.

It shares some parallels with the Vodun practised by the neighbouring Fon and Ewe peoples to its west and with the religion of the Edo people to its east. Yorùbá religion is the basis for several religions in the New World, notably Santería, Umbanda, Trinidad Orisha, and Candomblé. Yorùbá religious beliefs are part of Ìtàn (history), the total complex of songs, histories, stories, and other cultural concepts which make up the Yorùbá society.

The Yorùbá name for the Yorùbá indigenous religion is Ìṣẹ̀ṣẹ, which also refers to the traditions and rituals that encompass Yorùbá culture. The term comes from a contraction of the words Ìṣẹ̀ (Ishɛ), meaning "source/root origin", and ìṣe (Ishe), meaning "practice/tradition" coming together to mean "The original tradition"/"The tradition of antiquity" as many of the practices, beliefs, traditions, and observances of the Yorùbá originate from the religious worship of Olodumare and the veneration of the Òrìṣà.

According to Kola Abimbola, the Yorubas have evolved a robust cosmology. Nigerian Professor for Traditional African religions, Jacob K. Olupona, summarizes that central for the Yorùbá religion, and which all beings possess, is known as "Àṣẹ", which is "the empowered word that must come to pass," the "life force" and "energy" that "regulates all movement and activity in the universe". Every thought and action of each person or being in Ayé (the physical realm) interact with the Supreme force, all other living things, including the Earth itself, as well as with Ọ̀run (the otherworld), in which gods, spirits and ancestors exist. The Yorùbá religion can be described as a form of diffused monotheism, with a Supreme but distant creator force, encompassing the whole universe.

The anthropologist Robert Voeks described Yorùbá religion as being animistic, noting that it was "firmly attached to place".

Each person living on earth attempts to achieve perfection and find their destiny in Ọ̀run-Rere (the spiritual realm of those who do good and beneficial things).

One's orí-inú (spiritual consciousness in the physical realm) must grow in order to consummate union with one's "Ìpọ̀nrí" (Orí Ọ̀run, spiritual self).

Ìwà pẹ̀lẹ́ (or well-balanced) meditative recitation and sincere veneration are sufficient to strengthen the orí-inú of most people. Well-balanced people, it is believed, can make positive use of the simplest form of connection between their Ori and the omnipotent Olú-Ọ̀run: an Àwúre (petition or prayer) for divine support.