Yu with macron (Ю̄ ю̄; italics: Ю̄ ю̄) is a letter of the Cyrillic script. Its ligature is derived from the Cyrillic letter Yu (Юю) by adding a macron on top.

Yu with macron is used in the Aleut (Bering dialect), Evenki, Mansi, Nanai, Negidal, Orok, Ulch, Kildin Sami, and Selkup languages.