Yuri Alekseyevich Spiridonov (Russian: Юрий Алексеевич Спиридонов; 1 November 1938 – 12 August 2010), was a Russian politician who had served as a member of the State Duma of the IV convocation from 2003 to 2007.

Spirodov was known to be the first Head of the Komi Republic, having served from 1992 to 2002.

He had also been the First Secretary of the Komi Regional Committee of the CPSU from 1989 to 1990, Chairman of the Supreme Soviet of the Komi ASSR from 1990 to 1992.

Yuri Spirodonov was born in the village of Poltavka, Omsk Oblast on 1 November 1938 to a Russian family.

In 1961 he graduated from the Sverdlovsk Mining Institute with a degree in Mining Engineer.

In 1961, he worked at the Gorny mine in Magadan Oblast as a foreman, deputy section chief, senior mining foreman, and was elected chairman of the trade union committee.

From 1964 to 1975, he was a foreman, the head of a site, chief engineer, and head of an oil mine at the Yaregsky Oil Mine Administration in the Komi ASSR.

He was a member of the CPSU until August 1991.