Zhuxi County (simplified Chinese: 竹溪县; traditional Chinese: 竹谿縣; pinyin: Zhúxī Xiàn) is a county in the northwest of Hubei province, People's Republic of China, bordering Shaanxi to the west and Chongqing to the southwest. It is under the administration of the prefecture-level city of Shiyan. The county spans an area of 3,279 km² (1,266 sq mi), and has a population of 315,259 as of 2010.

The name Zhuxi County is named for the Zhuxi River, whose name (Chinese: 竹溪河; pinyin: Zhúxī Hé; lit. 'bamboo stream river') was derived from the large amounts of bamboo forests which bordered both sides of the river.

The area of present-day Zhuxi County once belong to the Chu State. Part of the remains of the Great Wall of Chu [zh], which possibly date back to the 3rd century BCE.

Zhuxi County was established in 1476 under the reign of the Chenghua Emperor.

In 1914, it was placed under the jurisdiction of Xiangyang Circuit [zh]. In 1932, the Republic of China introduced Administrative Inspectorates [zh], and the county was assigned to the 11th Administrative Inspectorate of Hubei Province. In 1936, it was reassigned to the 8th Administrative Inspectorate of Hubei Province.

In 1949, under the People's Republic of China, Zhuxi County was assigned to Liangyun Prefecture [zh], which was renamed to Yunyang Prefecture the following year.

The county was moved to Xiangyang Prefecture [zh] in 1952, but was moved back to Yunyang Prefecture in 1965.

In 1994, Zhuxi County was placed under the prefecture-level city of Shiyan, where it remains today.