The Anglo-Zulu War was fought in present-day South Africa from January to early July 1879 between forces of the British Empire and the Zulu Kingdom. Two famous battles of the war were the Zulu victory at Isandlwana and the British defence at Rorke's Drift.

Following the passing of the British North America Act 1867 forming a federation in Canada, Lord Carnarvon thought that a similar political effort, coupled with military campaigns, might lead to a ruling white minority over a black majority in South Africa. This would yield a large pool of cheap labour for the British sugar plantations and mines, and was intended to bring the African Kingdoms, tribal areas, and Boer republics into South Africa.

In 1874, Sir Bartle Frere was appointed as British High Commissioner for Southern Africa to effect such plans. Among the obstacles were the armed independent states of the South African Republic and the Zulu Kingdom.

Frere, on his own initiative, he then sent a quite highly provocative ultimatum on 11 December 1878 to Zulu King Cetshwayo. Upon its rejection, he ordered Lord Chelmsford to invade Zululand. The war had several particularly bloody battles, including an opening victory for the Zulu at the Battle of Isandlwana, followed by the defence of Rorke's Drift by a small British Garrison from an attack by a large Zulu force. However, the British eventually gained the upper hand at Kambula, before taking the Zulu capital of Ulundi. The British eventually won the war, ending Zulu dominance of the region. The British Empire made the Zulu Kingdom a protectorate and later annexed it in 1887.

The war dispelled prior colonial notions of British invincibility, due to their massive early defeats. Together with famines, diplomatic misadventures, and other unpopular wars overseas (such as the Second Anglo-Afghan War), it contributed to the ejection of Benjamin Disraeli's government from office in 1880, after only one term.

By the 1850s, the British Empire had colonies in southern Africa bordering on various Boer settlements, native African kingdoms such as the Zulus and the Basotho and numerous indigenous tribal areas and states. Various interactions with those groups followed an expansionist policy. Cape Colony was formed after the Anglo–Dutch Treaty of 1814 had permanently ceded the Dutch colony of Cape Town to Britain, and its territory expanded very substantially in the 19th century. Natal, in south-eastern Africa, was claimed by the British as a colony on 4 May 1843, after the British government had annexed the Boer Republic of Natalia. Matters were brought to a head when three sons (led by Mehlokazulu kaSihayo) and a brother of the Zulu inkosi Sihayo organized a raid into Natal and carried off two women who were under British protection.

The discovery of diamonds in 1867 near the Vaal River, some 550 mi (890 km) northeast of Cape Town, ended the isolation of the Boers in the interior and had a significant effect on events. The discovery triggered a diamond rush that attracted people from all over the world, which turned Kimberley into a town of 50,000 within five years and drew the attention of British imperial interests. In the 1870s, the British annexed West Griqualand, site of the Kimberley diamond discoveries.

In 1874 Lord Carnarvon, Secretary of State for the Colonies, who had brought about federation in Canada in 1867, thought that a similar scheme might work in South Africa, The South African plan called for a ruling white minority over a black majority, which would provide a large pool of cheap labour for the British sugar plantations and mines, Carnarvon, in an attempt to extend British influence in 1875, approached the Boer states of the Orange Free State and the Transvaal Republic and tried to organize a federation of the British and Boer territories but the Boer leaders turned him down.