Hubbry Logo
10x Genomics10x GenomicsMain
Open search
10x Genomics
Community hub
10x Genomics
logo
8 pages, 0 posts
0 subscribers
Be the first to start a discussion here.
Be the first to start a discussion here.
10x Genomics
10x Genomics
10x Genomics
View on Wikipedia
from Wikipedia

10x Genomics, Inc. is an American biotechnology company that designs and manufactures gene sequencing technology used in scientific research. It was founded in 2012 by Serge Saxonov, Ben Hindson, and Kevin Ness.[2]

Key Information

History

[edit]

10x Genomics was founded in 2012 by Serge Saxonov, Ben Hindson and Kevin Ness to create advanced testing equipment for use in cellular biology.[3] Prior to starting the company, Saxonov was the founding architect, and director of research and development at 23andMe.[2] Ness left 10x Genomics in December 2016[4] and in 2018, Justin McAnear, Tesla's former finance chief joined the company as CFO.[5]

In August 2018 the company announced its first acquisition, Epinomics, a biotechnology company focused on the development of new techniques for epigenetics research.[6] Four months later, 10x Genomics acquired Spatial Transcriptomics, a biotechnology company working in the field of spatial genomics.[7] In November 2018, 10x Genomics announced expansion plans including opening a manufacturing facility in Pleasanton, California in early 2019.[8]

10x Genomics announced its initial public offering on September 12, 2019, raising $390M.[9][10] The company had revenues of $3.32 million in 2015, $27.48 million in 2016, $71.18 million in 2017,[11] $145 million in 2018,[12] and $618.7 million in 2023.[13]

Arbitration and lawsuit

[edit]

Saxonov, Hindson, and Ness worked together at Quantalife prior to its acquisition by Bio-Rad in 2011 and left in 2012 to launch 10x Genomics. In 2014 an arbitration dispute was brought against the three cofounders by Bio-Rad, claiming they had breached obligations they allegedly owed to Bio-Rad after it acquired Quantalife. In 2015 an arbitrator determined that the founders of 10x Genomics had not breached their obligation to Bio-Rad when they left the company and denied its claims.[3]

In November 2018, a Delaware jury found that 10x Genomics infringed on several University of Chicago patents which were exclusively licensed to Bio-Rad. 10x Genomics were ordered to pay $24 million in damages to Bio-Rad and a 15% royalty on sales.[14][15] 10x Genomics appealed the verdict but the decision was upheld in August 2020.[16][17] In July 2021, Bio-Rad and 10x Genomics settled all outstanding lawsuits brought in American federal as well as international courts for an undisclosed amount and the rights for the companies to license each other's patents for single-cell analysis.[18]

References

[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

10x Genomics

View on Grokipedia
from Grokipedia
10x Genomics, Inc. is an American life sciences technology company headquartered in , that develops and commercializes innovative instruments, consumables, and software for high-throughput analysis of biological systems at single-cell, spatial, and resolutions. Founded in 2012 by Serge Saxonov, Ben Hindson, and Kevin Ness, the company emerged from prior collaborations at QuantaLife, Inc., with a vision to accelerate through scalable tools. Its mission is to fuel scientific discoveries and advance human health by enabling researchers to master via precise, multidimensional data generation. The company's core offerings center on three integrated platforms: the system for single-cell and , which encapsulates thousands of cells or nuclei into gel beads for simultaneous expression, protein, and epigenetic profiling; the Visium platform for , allowing whole-transcriptome mapping on tissue sections at subcellular resolution; and the Xenium platform for analysis, which detects targets directly in intact tissues with customizable panels up to 5,000 targets. These technologies support diverse applications, including immune profiling, screens, and antigen specificity assays, and are compatible with fresh, frozen, or formalin-fixed paraffin-embedded (FFPE) samples across , , and other . Recent advancements, such as the GEM-X series for flexible single-cell workflows and Xenium Protein for combined RNA-protein detection, enhance and capabilities. Since its inception, 10x Genomics has grown rapidly, placing over 4,600 instruments in leading academic, biopharmaceutical, and clinical institutions worldwide, securing more than 1,750 patents, and contributing to over 10,000 peer-reviewed publications that have advanced fields like , , and . The company went public on the (ticker: TXG) in September 2019, acquired Scale Biosciences in August 2025 to integrate quantum barcoding and combinatorial indexing for multi-million cell scale single-cell analysis of protein, gene expression, and epigenetics, and continues to innovate, with ongoing expansions in partnerships and cloud-based tools to democratize access to complex biological insights.

Overview

Founding and leadership

10x Genomics was founded in 2012 by Serge Saxonov, Ben Hindson, and Kevin Ness in . The company emerged from the founders' shared vision to create innovative solutions in , drawing on their prior experiences in and . Saxonov, who had served as a co-founder and executive at , brought strategic leadership; Hindson contributed expertise in single-cell technologies from his role at QuantaLife; and Ness provided engineering insights from his work at . From its inception, 10x Genomics focused on developing scalable tools for genomic analysis to accelerate biological discovery and enable researchers to tackle complex problems in biology. This initial emphasis aligned with the company's mission to deliver powerful, reliable tools that fuel scientific discoveries and drive exponential progress to master biology and advance human health. The company's headquarters remain in Pleasanton, California, where it employs approximately 1,306 people as of December 31, 2024. As of November 2025, Serge Saxonov continues to serve as , guiding the company's strategic direction and innovation efforts. Ben Hindson, a co-founder, holds the positions of President and , overseeing scientific advancements and contributing to key inventions in genomic technologies based on his background in chemistry and . The executive team also includes Michael Schnall-Levin as , responsible for product development; Mennah Moustafa as , managing global sales and marketing; Adam Taich as , handling financial operations; Jim Goodrich as , directing operational efficiency; and Eric Whitaker as Chief Legal Officer, leading legal affairs. On November 12, 2025, Eric Whitaker announced his retirement effective January 1, 2026, to be succeeded by Dr. Randy Wu as Chief Legal Officer.

Corporate structure and operations

10x Genomics, Inc. is a publicly traded company listed on the under the TXG, having gone public in September 2019. The company's centers on the development and sale of instruments, proprietary consumables, and software solutions designed exclusively for scientific applications, with no products approved or marketed for clinical or diagnostic use. 10x Genomics maintains its primary research and development (R&D) and manufacturing operations in , at its headquarters located at 6230 Stoneridge Mall Road, supplemented by a manufacturing and commercial hub in to enhance in the region. The company operates sales and support offices globally, including in (such as Leiden, Netherlands), (Shanghai, China, and ), and multiple locations across the (e.g., and , ). As of December 31, 2024, 10x Genomics employed 1,306 people worldwide, with approximately 92% of the based in the United States following an 8% global headcount reduction implemented in May 2025 to align with strategic priorities and reduce operating expenses. The company emphasizes diversity and inclusion initiatives, including ongoing efforts to foster a diverse and programs such as scholarships and fellowships aimed at supporting underrepresented groups in STEM fields. 10x Genomics collaborates extensively with academic institutions and biotechnology firms to validate and advance its technologies, exemplified by partnerships with the for large-scale single-cell datasets to train AI models in , and with the Arc Institute and Ultima Genomics to develop comprehensive cell atlases using high-throughput sequencing.

Products and technologies

Single-cell analysis platforms

The Chromium platform, launched by 10x Genomics in 2016, represents a cornerstone of high-throughput single-cell RNA sequencing (scRNA-seq) technology. It enables the simultaneous analysis of thousands of individual cells by partitioning them into gel beads-in-emulsion (GEMs) using microfluidic chips, where each cell is paired with a barcoded gel bead containing oligonucleotides for unique molecular identification and transcript capture. This GEM-based approach allows for the generation of barcoded cDNA libraries from single cells, facilitating downstream sequencing to profile gene expression at cellular resolution without prior cell sorting. Key features of the Chromium platform include its ability to process up to 10,000 cells per sample in standard workflows, delivering high cell recovery rates and low doublet rates for reliable data. It supports diverse applications, such as dissecting immune cell heterogeneity in immunological studies, identifying rare tumor subpopulations in oncology research, and mapping neuronal diversity in neuroscience investigations. For instance, in oncology, Chromium data has revealed tumor microenvironment dynamics, aiding in the discovery of therapeutic targets. The platform has evolved to meet demands for greater scale and sensitivity. The X instrument, introduced in 2021, enhances throughput by enabling experiments with up to 80,000 cells or more per run through improved and reagent delivery, supporting million-cell-scale analyses at reduced cost per cell. Further advancements came with GEM-X technology in 2024, which optimizes chemistry and capture to achieve up to 80% cell recovery and 40% higher gene detection, particularly for low-input or challenging samples like fixed tissues. In October 2025, 10x Genomics launched the next generation of the Flex assay, featuring plate-based multiplexing and automation compatibility to enable processing of up to 384 samples or 100 million cells per week, further scaling single-cell studies, and sponsored the Arc Institute Virtual Cell Challenge where winners utilized GEM-X Flex technology for high-quality single-cell data. Software tools are integral to the Chromium ecosystem for data processing and interpretation. Cell Ranger, a pipeline for alignment, quantification, and quality control, handles raw sequencing data to generate gene expression matrices, while Loupe Browser provides an intuitive interface for interactive visualization, clustering, and differential expression analysis. These tools integrate seamlessly with open-source platforms like Seurat, enabling researchers to explore datasets without extensive bioinformatics expertise. In October 2025, 10x Genomics partnered with Anthropic to integrate AI-driven analysis using Claude for Life Sciences, enhancing accessibility for single-cell and spatial data interpretation. As of 2025, the platform has driven significant scientific impact, with over 8,000 peer-reviewed publications leveraging its technology to advance fields from basic to clinical .

Spatial transcriptomics platforms

The Visium platform, developed by 10x Genomics, enables spatially resolved whole-transcriptome analysis by capturing mRNA from tissue sections onto arrays featuring barcoded spots, each approximately 55 microns in diameter, allowing mapping while preserving tissue architecture. This technology originated from the 2018 acquisition of AB, with the commercial launch of Visium occurring in late 2019. The platform supports unbiased profiling of thousands of genes across fresh-frozen or fixed tissues, integrating histological imaging such as H&E staining to correlate molecular data with morphological features. Key variants expand Visium's utility for diverse sample types and resolutions. Visium Spatial Gene Expression for FFPE, introduced in 2021, adapts the platform for formalin-fixed paraffin-embedded tissues using probe-based capture to overcome fixation-induced RNA degradation, enabling retrospective analysis of archived clinical samples. In 2024, Visium HD was launched, offering higher resolution with 2-micron spatial bins for near-single-cell-scale profiling, enabling detection of up to approximately 18,000 genes (whole transcriptome) and improving delineation of cellular heterogeneity. Applications of Visium have advanced understanding in and . In studies, it reveals spatial interactions between cancer cells, immune infiltrates, and stromal elements, such as identifying immunosuppressive niches in prostate . For , Visium maps gradients during embryogenesis, highlighting tissue patterning and cell fate transitions in model organisms. The Visium workflow begins with cryosectioning or processing of tissue samples (5-10 microns thick) onto specialized slides containing the capture array, followed by , permeabilization to release mRNA, and hybridization to spatial barcodes. Libraries are prepared via reverse transcription and PCR amplification, then sequenced on Illumina systems to generate paired-end reads that include spatial barcodes and unique molecular identifiers. is performed using software, which aligns reads to a , deconvolutes spots into cellular contributions, and overlays expression data onto tissue images for visualization. A significant advancement, the Visium CytAssist instrument, released in 2022, automates the transfer of analytes from standard glass slides to capture arrays, reducing hands-on time to about 8 hours over 2-3 days and enabling processing of up to four samples in parallel for improved throughput and reproducibility.

In situ analysis platforms

The Xenium platform, launched in 2022, is an imaging-based (ISH) system developed by 10x Genomics for high-plex of in tissue sections. It enables the detection of up to 5,000 genes per sample, providing transcript-level mapping while preserving native tissue architecture. This technology supports both fresh frozen and formalin-fixed paraffin-embedded (FFPE) samples, facilitating high-throughput profiling with results available in as little as six days. Key features of the Xenium platform include subcellular resolution at the nanometer scale, allowing precise localization of RNA transcripts within cells. It incorporates advanced decoding algorithms that assign gene identities to imaged signals using unique codewords, enhancing accuracy in multiplexed detection. In 2025, the platform expanded with Xenium Protein, enabling simultaneous and protein in the same tissue section, with support for up to 27 protein markers via ready-to-use subpanels. This multiomic capability reveals correlations between and protein localization at single-cell resolution. The platform finds applications in neurobiology, where it maps neuronal gene expression patterns to study brain disorders and cellular interactions, and in , particularly for profiling tumor microenvironments and immune responses in immuno-oncology contexts. Automated on the Xenium Analyzer instrument handles whole-slide acquisition with high speed, incorporating metrics and algorithmic error mitigation during transcript decoding to ensure reliable data. These features support detailed investigations into disease heterogeneity without tissue dissociation. The Xenium workflow begins with tissue sectioning onto specialized slides, followed by probe hybridization where gene-specific circular DNA probes bind to target transcripts. Subsequent ligation and rolling circle amplification (RCA) generate localized fluorescent signals for each transcript. The prepared slide is then loaded into the Xenium Analyzer for sequential imaging cycles, capturing morphology, , and protein signals across the entire tissue section. This process integrates signal amplification and decoding onboard the instrument. Data analysis is facilitated by the Xenium Explorer software, a desktop application that provides interactive visualization of transcripts, segmented cells, and co-expression patterns without requiring advanced bioinformatics expertise. It supports overlaying and protein data for multiomic insights. As of 2025, Xenium integrates with workflows, allowing combined transcript and protein datasets to be analyzed alongside complementary spatial technologies like Visium for broader tissue-scale context.

History

Formation and early innovations

10x Genomics was founded in July 2012 as Avante Biosystems, Inc., in , by Serge Saxonov, Ben Hindson, and Kevin Ness, with initial operations focused on developing advanced tools. This initial capital supported the transition from conceptual designs to practical implementation, marking the inception of a platform aimed at enhancing the resolution and throughput of sequencing applications. Early research and development at 10x Genomics centered on to address limitations in traditional genomic workflows, particularly for applications requiring high-resolution analysis of complex samples. By 2013, the team had developed an initial prototype leveraging emulsion-based techniques to partition and process genetic material, laying the groundwork for scalable solutions. This innovation built on the founders' prior expertise in microfluidics and sequencing, though details remained during this pre-commercial phase. The focus was on creating systems that could the intricacies of next-generation sequencing, where competition from established players like Illumina and emerging single-cell methods demanded improvements in throughput and cost-efficiency. In 2015, 10x Genomics launched its initial technology through the GemCode platform, introduced at the Advances in Genome Biology and Technology meeting, which enabled linked-read sequencing for structural variant detection. This marked the company's entry into the market, generating approximately $3 million in revenue that year from early adopters seeking enhanced genomic assembly capabilities. However, the nascent field presented challenges, including intense competition in next-generation sequencing tools and the need to scale microfluidic processes for reliable single-cell partitioning without compromising data quality or increasing costs. Between 2016 and 2018, 10x Genomics advanced its single-cell offerings with beta testing and early access programs for the platform, debuting in March 2016 to select researchers for feedback on droplet encapsulation and barcoding efficiency. Full commercial sales of the Single Cell Controller and associated Single Cell 3' Solution began later that year at the American Society of Human Genetics meeting, transitioning from prototype validation to widespread adoption in academic and biotech labs. This period solidified the company's emphasis on scalability, with iterative improvements addressing throughput limitations in single-cell applications amid a competitive featuring rivals like Fluidigm.

Expansion and public offering

In September 2019, 10x Genomics completed its (IPO) on the Global Select Market under the TXG, pricing 10 million shares at $39 each and raising approximately $390 million in gross proceeds. The IPO valued the company at around $3.6 billion and provided capital to support ongoing product development and global expansion, with shares opening higher and closing at $52.75 on the first . At the time of the IPO, the company employed 584 people, primarily in , , and operations. Following the IPO, 10x Genomics experienced significant revenue growth, increasing from $245.9 million in to $618.7 million in 2023, largely driven by recurring sales of that complement its instrument platforms. This trajectory reflected broader adoption of its single-cell and spatial technologies in academic, biopharma, and settings. By the end of 2023, the company had achieved over 5,966 cumulative instrument installations worldwide, including more than 5,180 systems, underscoring the scalability of its . The period from 2020 to 2023 was marked by challenges from the , which disrupted funding and laboratory operations globally, yet also accelerated demand for 10x Genomics' tools in immunology . In response, the company pivoted toward enhancing its immune profiling capabilities, launching the V(D)J solution for in July 2020 to support studies of adaptive immune responses, including those related to SARS-CoV-2. This strategic focus helped mitigate funding shifts, contributing to sustained growth amid pandemic-related volatility. Concurrently, 10x Genomics expanded into the market, opening a and commercial hub in in October 2021 to bolster and serve the region's growing , which accounted for about 25% of global sales by mid-2021. Employee headcount grew to 1,259 by December 31, 2023, supporting enhanced R&D (451 employees) and commercial efforts.

Key acquisitions and product launches

In 2018, 10x Genomics made two significant acquisitions to enhance its technological capabilities in emerging fields of genomics. The company acquired Epinomics in August, gaining access to advanced ATAC-seq technology and intellectual property focused on epigenetics research, which aimed to accelerate discoveries in gene regulation and chromatin accessibility. Later that year, in December, 10x Genomics acquired Spatial Transcriptomics, a Stockholm-based pioneer in spatial genomics, for an undisclosed amount; this move integrated Spatial Transcriptomics' slide-based technology for mapping gene expression in tissue sections, strengthening 10x Genomics' portfolio in spatial biology. Building on the Spatial Transcriptomics acquisition, 10x Genomics launched the Visium Spatial Gene Expression platform in November 2019, marking its entry into commercial with an instrument-free workflow for whole-transcriptome analysis in intact tissues. In December 2022, the company debuted the Xenium platform, introducing high-throughput, subcellular-resolution imaging for up to 5,000 genes in tissue samples, compatible with fresh frozen and FFPE tissues via targeted panels. From 2023 to 2024, 10x Genomics advanced its spatial and single-cell offerings with several key product introductions and upgrades. In May 2023, it launched the Visium CytAssist instrument and associated gene and protein expression assay, enabling automated processing of standard glass slides for enhanced tissue profiling and integration with existing Visium workflows. In February 2024, the GEM-X technology was introduced as a major upgrade to the Chromium single-cell platform, featuring improved emulsion chemistry for higher cell capture efficiency and scalability in gene expression analysis. Later that year, in early 2024, Visium HD was released, providing near-single-cell resolution spatial transcriptomics with 2-micron pixel size for detailed gene expression mapping in FFPE samples. In October 2024, the GEM-X Flex was launched, offering plate-based multiplexing to process up to 384 samples or 100 million cells per week, reducing per-cell costs to as low as one cent and supporting large-scale studies across diverse sample types. In 2025, 10x Genomics continued its innovation momentum with launches emphasizing scalability and integration. In August, the company launched Xenium Protein, a extension to the Xenium platform that enables simultaneous detection of and proteins in the same tissue section using pre-designed subpanels for up to 30 proteins, facilitating deeper insights into cellular heterogeneity. These acquisitions and launches strategically bolstered 10x Genomics' spatial biology portfolio by incorporating complementary technologies and expanded its market share in single-cell and , contributing to sequential revenue growth in subsequent quarters.

Arbitration with Bio-Rad

In 2014, initiated an claim against the founders of 10x Genomics—Serge Saxonov, Benjamin Hindson, and Kevin Ness—alleging that they had breached non-compete, , and obligations stemming from their prior employment at QuantaLife, a company acquired by in 2011. The dispute centered on claims that the founders had misappropriated trade secrets and violated restrictive covenants by establishing 10x Genomics and developing competing droplet-based microfluidic technologies. The arbitration proceedings took place before the , where Bio-Rad sought to enforce the alleged breaches and potentially impose restrictions on the founders' activities at 10x Genomics. In a ruling issued in 2015, the arbitrator fully denied Bio-Rad's claims, determining that the founders had not breached any of the specified obligations and awarding no damages to Bio-Rad. Furthermore, the decision allowed the 10x founders to pursue recovery of their attorneys' fees and costs from the proceedings. The outcome of the arbitration cleared the founders of any wrongdoing, validating their right to operate 10x Genomics independently without ongoing restrictions from their prior employment agreements. This resolution removed a significant legal hurdle early in the company's development, enabling 10x Genomics to focus on commercializing its innovative single-cell and spatial genomics platforms.

Patent infringement disputes

In 2018, Bio-Rad Laboratories and the University of Chicago filed a patent infringement lawsuit against 10x Genomics in the U.S. District Court for the District of Delaware, alleging that 10x's Single Cell and Linked-Read genomics products infringed three patents related to droplet microfluidics technology licensed exclusively to Bio-Rad: U.S. Patent Nos. 9,689,025; 9,626,712; and 9,995,656. A jury found the infringement willful and awarded Bio-Rad approximately $24 million in damages, calculated based on a reasonable royalty rate of 15% on 10x's net revenues from the infringing products. The district court subsequently granted Bio-Rad's motion for a permanent injunction, which required 10x to pay a 15% royalty on net revenues from sales of certain installed base products until the patents expired, along with supplemental damages exceeding $10 million for post-verdict sales. In August 2020, the U.S. Court of Appeals for the Federal Circuit affirmed the jury's validity and infringement findings for one of the patents, upheld the damages award, and confirmed the willfulness determination, though it remanded for further proceedings on two other patents under a revised claim construction. The parties reached a global settlement in July 2021, under which 10x agreed to pay Bio-Rad $29.4 million in royalties and interest on GEM product sales, and both granted each other non-exclusive, royalty-bearing cross-licenses for single-cell technologies, resolving all ongoing litigations. From 2022 onward, 10x Genomics initiated several actions to protect its innovations in single-cell and , often involving acquired through company purchases such as Cartana and ReadCoor for and spatial technologies. In October 2022, 10x sued Parse Biosciences in federal court, claiming infringement of patents covering gel bead emulsion (GEM) technology for single-cell sequencing, including U.S. No. 10,851,394. The dispute escalated, with Parse challenging the validity of several 10x patents. On February 4, 2025, the Trial and Appeal Board invalidated all of 10x Genomics' patent claims asserted against Parse's core single-cell products. In February 2025, the court upheld the validity and infringement of 10x's patents (U.S. Nos. 10,577,722 and 11,299,737), leading to a injunction entered on March 3, 2025, that barred Parse from manufacturing, using, selling, or offering its planned ATAC products; the remaining trial claims were subsequently dropped. Later, Parse successfully invalidated claims in U.S. No. 11,028,752 for lack of written and enablement on October 9, 2025. In June 2023, 10x, along with , sued Vizgen in federal court for infringing patents on sequencing and analysis, including U.S. Nos. 10,408,590 and 10,557,201 licensed from Harvard's George Church lab, alleging Vizgen's MERFISH technology copied 10x's Xenium platform methods acquired via ReadCoor. Vizgen countersued, raising antitrust claims that were dismissed at in 2024. The case proceeded to trial in February 2025 but settled on , 2025, with terms undisclosed, ending all U.S. and European litigations and allowing Vizgen to continue operations under the agreement. 10x also pursued claims against NanoString Technologies (acquired by in 2024), filing suit in 2023 over patents, including those from the 2020 Cartana acquisition covering methods (e.g., U.S. No. 11,091,757). The parties resolved the disputes through a global settlement announced on May 14, 2025, in which agreed to pay 10x $68 million in quarterly installments from Q3 2025 to Q2 2026, plus ongoing royalties on NanoString's CosMx and GeoMx products, granting mutual cross-licenses for single-cell and spatial technologies. Most recently, on October 21, 2025, 10x Genomics, joined by Prognosys Biosciences and , filed two lawsuits in federal court against Illumina, alleging infringement of nine patents related to single-cell partitioning and , including U.S. Patent Nos. 10,865,428 and 11,066,773 from Prognosys (acquired by 10x in 2023) and others covering barcoding and multi-omics integration. The suits target Illumina's Visium and PIPseq platforms, as well as technologies from its 2024 acquisition of Fluent Biosciences, claiming willful infringement that threatens 10x's market leadership. As of November 2025, the cases remain ongoing, with no trial date set. These disputes have resulted in multiple favorable settlements for 10x Genomics, reinforcing its portfolio and generating over $100 million in payments while limiting competitors' offerings in single-cell and spatial markets, thereby shaping industry dynamics around licensed access to core technologies.

Financial performance

Revenue growth and profitability

In 2024, 10x Genomics reported of $610.8 million, representing a 1% decline from $618.7 million in 2023, primarily due to softer demand in academic and sectors amid macroeconomic pressures. The company recorded a net loss of $182.6 million for the year, an improvement from $255.1 million in 2023, driven by reduced operating expenses. Total assets stood at $918.6 million as of December 31, 2024. Entering 2025, the company's financial performance showed mixed quarterly trends, reflecting a recovery from the prior year's dip through core operations despite one-time items. In the first quarter, reached $154.9 million, up 10% year-over-year, though adjusted excluding license and royalty fees was $138.1 million, down 2%. The second quarter saw total of $172.9 million, boosted by a $27.3 million litigation settlement, with core at $145.6 million. Third-quarter totaled $149.0 million, a 2% year-over-year decline but a 2% sequential increase from core second-quarter figures, with consumables contributing $127.9 million or approximately 86% of total . Net loss narrowed to $27.5 million in the third quarter, compared to $35.8 million in the prior-year period. Based on the Q4 guidance, full-year 2025 is projected to be approximately $630-634 million on a total basis, though core (excluding settlements) would be near 2024 levels. Profitability remained challenged by substantial investments, with quarterly R&D expenses around $61-66 million, projecting an annual spend exceeding $250 million, alongside gross margins averaging 67-72% across quarters due to product mix shifts and inventory adjustments. Key drivers include lumpy instrument cycles, which accounted for about 12% of third-quarter , and the recurring consumables model, historically comprising 80% of overall to support steady from high-volume single-cell and spatial applications. Looking ahead, 10x Genomics anticipates fourth-quarter 2025 revenue of $154-158 million, implying 3-6% sequential growth and positioning full-year results near 2024 levels on a core basis. Growth is expected to accelerate in 2026 from launches like the next-generation Flex platform, enhancing throughput for and addressing prior demand softness in consumables.

Market position and stock history

10x Genomics holds a leading position in the single-cell market, as a key player among the top five companies that collectively control 70-75% of the product segment share as of 2025, driven by its platform's dominance in high-throughput applications. Key competitors include Illumina, which focuses on broader sequencing technologies; Becton Dickinson (BD), offering Rhapsody systems for ; and NanoString Technologies, specializing in via GeoMx and CosMx platforms. The company's market strength stems from its integrated workflows for single-cell sequencing and , capturing a consolidated segment where the top five players control 70-75% of the market. The company went public on September 12, 2019, pricing its at $39 per share and raising approximately $390 million, with shares closing at $52.75 on the first trading day. performance peaked at $202.37 per share in 2021 amid high investor enthusiasm for during the post-pandemic biotech boom. However, shares experienced significant volatility, declining sharply in subsequent years due to broader biotech sector challenges, including constraints and economic pressures; by November 2025, the stock traded around $16-17 per share, reflecting a 92.5% drop from its peak. This downturn aligned with stalled revenue growth projections of 0-3% for 2025, exacerbating share price pressure. As of November 2025, 10x Genomics' hovered between $1.9 billion and $2.1 billion, positioning it as a mid-cap player in the life sciences tools sector. Analyst ratings remain mixed, with a consensus "Hold" from 16 firms and an average price target of $15, emphasizing potential upside from spatial biology expansions like the Xenium platform despite ongoing profitability concerns. Stock movements in 2024-2025 were influenced by macroeconomic factors, including rising interest rates and reduced venture in biotech, contributing to sector-wide volatility with TXG's beta exceeding 1.98. Positive catalysts included patent settlements, such as the May 2025 agreement with for $68 million in payments through 2026, which boosted investor confidence and led to a 5-10% share price increase following announcements. Similarly, resolutions with Vizgen in early 2025 cleared antitrust hurdles, supporting market perception of strengthened defenses. Looking ahead, analysts highlight 10x Genomics' focus on integration—combining single-cell with spatial and data—as a key driver for clinical translation in and , potentially expanding applications beyond into diagnostics by 2030. This strategic emphasis, alongside robust growth in spatial (up significantly in Q3 2025), positions the company for recovery amid a projected single-cell market expansion to $13.7 billion by 2030.

References

  1. https://www.10xgenomics.com/company
  2. https://www.globaldata.com/company-profile/10x-genomics-inc/
  3. https://www.10xgenomics.com/company/team/serge-saxonov
  4. https://www.10xgenomics.com/company/team/ben-hindson
  5. https://www.biocentury.com/article/252216/how-10x-genomics-is-unlocking-the-genome
  6. https://www.10xgenomics.com/products
  7. https://www.10xgenomics.com/platforms/visium/product-family
  8. https://www.10xgenomics.com/platforms/xenium
  9. https://www.10xgenomics.com/blog/the-next-generation-of-single-cell-rna-seq-an-introduction-to-gem-x-technology
  10. https://www.prnewswire.com/news-releases/10x-genomics-launches-xenium-protein-advancing-spatial-biology-by-enabling-same-cell-rna-and-protein-analysis-302532774.html
  11. https://www.crunchbase.com/organization/10x-genomics
  12. https://www.sptlabtech.com/news/spt-labtech-partners-with-10x
  13. https://www.prnewswire.com/news-releases/10x-genomics-to-acquire-scale-biosciences-302524711.html
  14. https://scale.bio/new/10x-genomics-to-acquire-scale-biosciences/
  15. https://matrixbcg.com/blogs/owners/10xgenomics
  16. https://www.10xgenomics.com/blog/a-message-from-our-cofounders-our-commitment-to-innovation
  17. https://stockanalysis.com/stocks/txg/employees/
  18. https://s28.q4cdn.com/592666581/files/doc_downloads/kit/2025/TXG-2025-DEF-14A.pdf
  19. https://www.prnewswire.com/news-releases/10x-genomics-announces-senior-leadership-changes-302218349.html
  20. https://www.sec.gov/Archives/edgar/data/1770787/000162828025052154/txg-20251112.htm
  21. https://stockstory.org/us/stocks/nasdaq/txg
  22. https://www.10xgenomics.com/
  23. https://www.prnewswire.com/news-releases/10x-genomics-celebrates-opening-of-singapore-manufacturing-and-commercial-hub-301407271.html
  24. https://craft.co/10x-genomics/locations
  25. https://www.zippia.com/10x-genomics-careers-1413818/locations/
  26. https://matrixbcg.com/blogs/growth-strategy/10xgenomics
  27. https://s28.q4cdn.com/592666581/files/doc_financials/2020/q4/0001770787-21-000009.pdf
  28. https://www.youtube.com/watch?v=i9SOtw_Ad-8
  29. https://www.prnewswire.com/news-releases/chan-zuckerberg-initiative-launches-billion-cells-project-with-10x-genomics-and-ultima-genomics-to-advance-ai-in-biology-302369647.html
  30. https://arcinstitute.org/news/arc-10x-ultima
  31. https://www.10xgenomics.com/blog/ashg-2016-round-up
  32. https://www.10xgenomics.com/platforms/chromium/technology
  33. https://www.10xgenomics.com/support/universal-five-prime-gene-expression/documentation/steps/library-prep/chromium-next-gem-single-cell-5-ht-v-2-reagents-workflow-and-data-overview
  34. https://www.10xgenomics.com/platforms/chromium/applications
  35. https://www.10xgenomics.com/publications
  36. https://www.10xgenomics.com/blog/increasing-the-power-of-single-cell-resolution-with-expanded-flexibility-and-scale-introducing-chromium-x
  37. https://www.prnewswire.com/news-releases/10x-genomics-launches-the-next-generation-of-chromium-flex-to-empower-scientists-to-massively-scale-single-cell-research-302597705.html
  38. https://www.genengnews.com/topics/artificial-intelligence/neurips-2025-altos-labs-wins-generalist-prize-at-arcs-virtual-cell-challenge/
  39. https://arcinstitute.org/news/virtual-cell-challenge-2025-wrap-up
  40. https://www.10xgenomics.com/products/chromium-analysis
  41. https://www.prnewswire.com/news-releases/10x-genomics-and-anthropic-partner-to-make-single-cell-and-spatial-analysis-more-accessible-through-claude-for-life-sciences-302588055.html
  42. https://www.10xgenomics.com/platforms/visium
  43. https://www.scilifelab.se/news/10x-genomics-acquires-spatial-transcriptomics/
  44. https://www.fiercebiotech.com/medtech/10x-genomics-debuts-gene-expression-mapping-tech
  45. https://www.10xgenomics.com/support/spatial-gene-expression-ffpe
  46. https://www.prnewswire.com/news-releases/10x-genomics-commercially-launches-visium-hd-spatial-gene-expression-assay-302099533.html
  47. https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-024-02040-9
  48. https://link.springer.com/article/10.1186/s43556-023-00144-0
  49. https://www.10xgenomics.com/products/visium-analysis
  50. https://www.10xgenomics.com/instruments/visium-cytassist
  51. https://www.10xgenomics.com/blog/optimizing-your-spatial-transcriptomics-research-with-visium-hd-and-xenium-in-situ
  52. https://biopharmaapac.com/news/37/2298/10x-genomics-commercially-launches-xenium-platform-for-in-situ-analysis.html
  53. https://www.10xgenomics.com/support/software/xenium-onboard-analysis/latest/algorithms-overview/xoa-algorithms
  54. https://www.drugtargetreview.com/article/169606/what-single-cells-are-revealing-about-brain-disorders/
  55. https://www.nature.com/articles/s41467-023-43458-x
  56. https://www.10xgenomics.com/in-situ-technology
  57. https://www.sec.gov/Archives/edgar/data/1770787/000119312519224368/d737378ds1.htm
  58. https://www.foresitecapital.com/portfolio/10x-genomics/
  59. https://axial.substack.com/p/axial-how-successful-tools-companies
  60. https://www.decibio.com/insights/10x-genomics-dominates-the-single-cell-landscape-while-competitors-look-for-a-niche
  61. https://www.rna-seqblog.com/10x-genomics-announces-commercial-availability-of-single-cell-3-solution-at-the-aacr-annual-meeting-2016/
  62. https://www.globenewswire.com/news-release/2019/09/12/1914653/0/en/10x-Genomics-Announces-Pricing-of-Initial-Public-Offering.html
  63. https://www.sec.gov/Archives/edgar/data/1770787/000119312519243349/d737378d424b4.htm
  64. https://www.wsj.com/articles/10x-genomics-valued-at-3-6-billion-in-ipo-11568294932
  65. https://www.sec.gov/Archives/edgar/data/1770787/000119312520052640/d849320d10k.htm
  66. https://s28.q4cdn.com/592666581/files/doc_news/2020/2/18/10x-genomics-reports-fourth-quarter-and-full-year-2019-financial.pdf
  67. https://s28.q4cdn.com/592666581/files/doc_news/2024/02/TXG_Q4-2023_Earnings-Press-Release-vF.pdf
  68. https://s28.q4cdn.com/592666581/files/doc_financials/2023/q4/47a22a36-aa5e-49b1-a981-a58a82fe9a4d.pdf
  69. https://www.biospace.com/10x-genomics-provides-covid-19-business-impact-update-and-response
  70. https://www.biospace.com/10x-genomics-launches-next-generation-immune-profiling-product-to-combat-covid-19delivers-major-improvements-for-discoveries-in-immunology-oncology-autoimmunity-and-infectious-diseases
  71. https://www.cnbc.com/2018/08/28/sofbtank-backed-10x-genomics-buys-epinomics.html
  72. https://www.prnewswire.com/news-releases/10x-genomics-acquires-spatial-transcriptomics-300762546.html
  73. https://www.globenewswire.com/news-release/2019/11/26/1952684/0/en/10x-Genomics-Begins-Shipments-of-Visium-Spatial-Gene-Expression-Solution.html
  74. https://www.prnewswire.com/news-releases/10x-genomics-commercially-launches-xenium-platform-for-in-situ-analysis-301698748.html
  75. https://www.prnewswire.com/news-releases/10x-genomics-launches-visium-cytassist-gene-and-protein-expression-assay-301833960.html
  76. https://www.prnewswire.com/news-releases/10x-genomics-expands-leadership-in-single-cell-analysis-with-launch-of-gem-x-technology-302056515.html
  77. https://www.liebertpub.com/doi/10.1089/genedge.6.01.057
  78. https://www.biospace.com/press-releases/10x-genomics-delivers-single-cell-for-a-single-cent-with-new-chromium-launches
  79. https://seekingalpha.com/news/4518220-10x-genomics-signals-5-percent-sequential-revenue-growth-for-q4-2025-as-new-product-launches
  80. https://www.genomeweb.com/business-news/10x-genomics-founders-prevail-arbitration-dispute-bio-rad
  81. https://www.reuters.com/legal/transactional/bio-rad-10x-genomics-settle-genomics-patent-war-2021-07-27/
  82. https://investors.bio-rad.com/press-releases/news-details/2018/Bio-Rad-and-the-University-of-Chicago-Win-Patent-Infringement-Case-Against-10X-Genomics-Related-to-Droplet-Microfluidics-Technologies-11-14-2018/default.aspx
  83. https://law.justia.com/cases/federal/appellate-courts/cafc/19-2255/19-2255-2020-08-03.html
  84. https://ipwatchdog.com/2018/11/26/jury-awards-24-million-bio-rad-10x-genomics-infringement-willful/
  85. https://www.liebertpub.com/doi/full/10.1089/blr.2020.29203.cmh
  86. https://www.knobbe.com/blog/court-enters-permanent-injunction-and-34-million-judgment-bio-rad-against-10x-genomics/
  87. https://www.genengnews.com/topics/omics/10x-genomics-ipo-starts-out-strong-as-bio-rad-files-third-patent-lawsuit/
  88. https://investors.bio-rad.com/press-releases/news-details/2020/The-United-States-Court-of-Appeals-for-the-Federal-Circuit-Affirms-that-10x-Genomics-Willfully-Infringed-Bio-Rad-U-S--Patent-and-Upholds-Lower-Courts-Award-of-Damages-08-04-2020/default.aspx
  89. https://content.edgar-online.com/ExternalLink/EDGAR/0001770787-21-000039.html?hash=f10d0fbdefbcb2d42879c36a3933b7ca620f7fc075beb60e5dc042004bf91922&dest=a10xexhibit101_htm
  90. https://investors.bio-rad.com/press-releases/news-details/2021/Bio-Rad-and-10x-Genomics-Announce-Settlement-to-Resolve-Multiple-Litigations-07-27-2021/default.aspx
  91. https://www.prnewswire.com/news-releases/10x-genomics-secures-injunction-against-parse-biosciences-planned-atac-products-302390537.html
  92. https://www.parsebiosciences.com/news/parse-biosciences-invalidates-all-10x-genomics-patent-claims-asserted-against-its-products/
  93. https://www.investing.com/news/company-news/10x-genomics-secures-injunction-against-parse-biosciences-93CH-3903982
  94. https://www.parsebiosciences.com/news/parse-biosciences-invalidates-scale-biosciences-now-10x-genomics-patent/
  95. https://www.thecrimson.com/article/2025/2/22/harvard-10x-vizgen-lawsuit-settled/
  96. https://www.thepatentplaybook.com/2025/02/10x-genomics-and-harvard-overcome-patent-and-antitrust-hurdles-after-settling-with-vizgen-inc/
  97. https://www.tensegritylawgroup.com/notablesuccesses/
  98. https://www.reuters.com/legal/government/10x-harvard-settle-genomics-patent-dispute-with-vizgen-during-trial-2025-02-06/
  99. https://vizgen.com/vizgen-announces-end-of-litigation-with-10x-genomics-and-harvard-university/
  100. https://www.genomeweb.com/business-news/bruker-pay-10x-genomics-68m-under-global-settlement-patent-disputes
  101. https://www.stocktitan.net/news/TXG/10x-genomics-announces-patent-litigation-settlement-agreement-with-88k957dt11xg.html
  102. https://www.reuters.com/legal/litigation/10x-sues-rival-illumina-over-gene-sequencing-patents-2025-10-21/
  103. https://ipwatchdog.com/2025/10/23/10x-genomics-prognosys-biosciences-allege-illumina-infringed-four-spatial-transcriptomics-patents/
  104. https://dockets.justia.com/docket/delaware/dedce/1:2025cv01287/90879
  105. https://www.genengnews.com/topics/omics/10x-settles-bruker-vizgen-patent-lawsuits/
  106. https://www.genomeweb.com/business-news/10x-genomics-sue-illumina-alleging-infringement-single-cell-spatial-patents
  107. https://www.prnewswire.com/news-releases/10x-genomics-reports-fourth-quarter-and-full-year-2024-financial-results-and-provides-outlook-for-2025-302375081.html
  108. https://www.prnewswire.com/news-releases/10x-genomics-reports-third-quarter-2025-financial-results-302607636.html
  109. https://www.prnewswire.com/news-releases/10x-genomics-reports-first-quarter-2025-financial-results-302450468.html
  110. https://www.sec.gov/Archives/edgar/data/1770787/000177078725000048/txg-20250807xexx991.htm
  111. https://s28.q4cdn.com/592666581/files/doc_financials/2025/q2/7bf3ab5e-a9bb-4cd1-817a-0ea19cc3fb32.pdf
  112. https://investors.10xgenomics.com/news/default.aspx
  113. https://www.globenewswire.com/news-release/2025/08/21/3137124/0/en/Global-Single-Cell-Sequencing-Market-to-Reach-USD-3-46-Billion-by-2030-MarketsandMarkets.html
  114. https://www.marketsandmarkets.com/ResearchInsight/single-cell-sequencing-market.asp
  115. https://dividendstocks.cash/stock-profile/10x%2520Genomics-Stock
  116. https://www.macrotrends.net/stocks/charts/TXG/10x-genomics/stock-price-history
  117. https://www.nanalyze.com/2025/06/10x-genomics-is-single-cell-sequencing-too-niche/
  118. https://www.marketwatch.com/investing/stock/txg?gaa_at=eafs&gaa_n=AWEtsqfo0txX-uSqZspZNeq-1wKQZlyJ8cXR_nkiLROkbGtVXCIZIj3Y4M4I&gaa_ts=69128f7d&gaa_sig=KX30oXwg68zh0FHE9Ynz_Cp-AtxfZJwFXcP1dx5Vz8_v2ncvKQs00pNIBoyWLOb0GtY0j3P4wiDTzN-9zw5tpw%253D%253D
  119. https://www.marketbeat.com/stocks/NASDAQ/TXG/forecast/
  120. https://www.10xgenomics.com/pharma
  121. https://www.rdworldonline.com/10x-genomics-scales-single-cell-analysis-platform-amid-growing-market-demand/
Add your contribution
Related Hubs
User Avatar
No comments yet.