The 1980 Tournament Players Championship was a golf tournament in Florida on the PGA Tour, held March 20–23 at Sawgrass Country Club in Ponte Vedra Beach, southeast of Jacksonville. The seventh Tournament Players Championship, it was the fourth at Sawgrass and Lee Trevino won at 278 (−10), one stroke ahead of runner-up Ben Crenshaw.

Defending champion Lanny Wadkins finished thirteen strokes back, in a tie for 45th place.

This was the fourth of five Tournament Players Championships held at Sawgrass Country Club; it moved to the nearby TPC at Sawgrass Stadium Course in 1982. At the time it was scheduled to be the last at Sawgrass, but early construction delays due to weather caused the championship to return for a fifth and final year in 1981.

1. All designated players

Andy Bean (2), Ben Crenshaw (2), Lee Elder, Raymond Floyd (2), Al Geiberger (2), Bob Gilder, David Graham (2), Lou Graham (2), Hubert Green (2), Mark Hayes, Lon Hinkle (2), Hale Irwin (2), Tom Kite, Wayne Levi (2), Bruce Lietzke, John Mahaffey, Jerry McGee (2), Gil Morgan (2), Larry Nelson (2), Jack Nicklaus, Andy North, Jerry Pate, Calvin Peete (2), Gary Player, Tom Purtzer, Jack Renner (2), Bill Rogers, J. C. Snead, Ed Sneed, Dave Stockton, Curtis Strange (2), Lee Trevino (2), Howard Twitty (2), Bobby Wadkins, Lanny Wadkins (2), Tom Watson (2), Fuzzy Zoeller (2)

2. Winners of major PGA Tour co-sponsored or approved events beginning with the 1979 Players Championship and concluding with the tournament immediately preceding the 1980 Players Championship

Bobby Walzel, Chi-Chi Rodríguez, D. A. Weibring, John Fought, Ed Fiori, George Burns, Craig Stadler, Jeff Mitchell, Jim Colbert, Dave Eichelberger, Johnny Miller

3. The current British Open champion