The 1992 Brazilian Grand Prix (formally the XXI Grande Prêmio do Brasil) was a Formula One motor race held at Interlagos on 5 April 1992. It was the third race of the 1992 Formula One World Championship.

The 71-lap race was won by Englishman Nigel Mansell, driving a Williams-Renault, after he started from pole position. Mansell's Italian teammate, Riccardo Patrese, finished second after leading the first 31 laps, with German Michael Schumacher third in a Benetton-Ford.

Going into the race, the two major talking points were Williams' utter domination of the previous two races, as well as McLaren's response to that domination: the new MP4/7A would debut at Interlagos, despite having originally been scheduled to debut at Barcelona. However, the car was still experiencing teething issues, despite an intensive testing programme at Silverstone following the Mexican Grand Prix. The team brought a total of six complete cars to the race, including three MP4/6Bs to be tested alongside the MP4/7A.

For the first time in 1992, there was a need for a pre-qualifying hour on Friday morning. The pool consisted of six cars, which needed to be reduced to four to ensure the maximum of thirty cars in the main qualifying sessions. The entrants were the two Lamborghini-powered Venturi LC92 cars entered by the Larrousse team, and driven by Bertrand Gachot and Ukyo Katayama; the Footwork FA13-Mugen-Honda of Michele Alboreto; the Fondmetal GR01 of Andrea Chiesa, and the two Andrea Moda S921s of Roberto Moreno and Perry McCarthy. Moreno and McCarthy had been recruited by Andrea Moda after team boss Andrea Sassetti had fired both his drivers (Alex Caffi and Enrico Bertaggia) after they had criticised the amateurish way the team had been run thus far.

With very little time to prepare, McCarthy had hastily acquired a FISA Super Licence which enabled him to compete in Formula One. However, when he arrived at Interlagos, his licence was rescinded by race director Roland Bruynseraede, who told him there had been an error in the issuing of the licence, so McCarthy was withdrawn from the event. In any case, the team had not finished building his car in time, so he would not have driven in the session anyway.

This left five cars in the session, and it became clear which four were to progress when the remaining Andrea Moda of Roberto Moreno managed just two laps before it broke down, having posted a very slow time. The other four cars were over fifteen seconds faster, with Gachot's Venturi topping the time sheets. Alboreto was just under two tenths of a second slower, with Chiesa third in the Fondmetal. Fourth was Katayama, just over a second slower than his team-mate Gachot. Thus Moreno failed to pre-qualify.

The Williams cars were ahead of the McLarens with Mansell on pole ahead of Patrese, with Senna third in front of his home crowd ahead of Berger, Schumacher, and Alesi. There was controversy in the second qualifying session, as Senna slowed in front of an over-enthusiastic Mansell, forcing him wide on the entry to turn 11 and into a spin. Having been collected by the outside wall, Mansell limped out of his damaged Williams. Berger's time was set in one of the MP4/6B's, as he suffered an engine failure in his primary car, an MP4/7A; however, he raced an MP4/7A on raceday. As of 2024^[update], this was the last time a woman, Giovanna Amati, took part in the World Championship (Amati would be sacked by Brabham after this race and replaced by Englishman Damon Hill, son of late and two-time World Champion Graham Hill).

On the parade lap, Gerhard Berger stalled and had to start at the back. Mansell’s start was poor and Patrese blasted ahead of him with Brundle getting ahead of Alesi. The order from there was Patrese, Mansell, Senna, Schumacher, Brundle and Alesi. Berger had to retire after only four laps in the pits with electrical failure. Both Williams cars pulled away while Senna was holding the rest at bay; Schumacher was thirty seconds behind by the time he had passed Senna for third on lap 13. Martin Brundle and Jean Alesi passed him soon afterwards and Senna retired with engine problems on lap 17.