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1H-LSD
1H-LSD
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1H-LSD

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1H-LSD

1H-LSD, also known as 1-hexanoyl-LSD or as SYN-L-027, is an acylated derivative of lysergic acid diethylamide (LSD), with a six carbon hexanoyl chain attached to the N1 position. It acts as a prodrug for LSD, and in animal studies produces drug-appropriate responding with a similar potency to short-chain homologues such as ALD-52 and 1P-LSD, in contrast to the 4 and 5 carbon homologues 1B-LSD and 1V-LSD which are several times weaker.

1H-LSD produces similar effects to LSD with a shorter metabolic half-life.[citation needed] There are no documented cases of it being used recreationally.

Analogues of 1H-LSD include ALD-52 (1A-LSD), 1P-LSD, 1cP-LSD, 1DD-LSD, 1cP-AL-LAD, and 1P-ETH-LAD, among others.

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