2001 Mars Odyssey is a robotic spacecraft orbiting the planet Mars. The project was developed by NASA, and contracted out to Lockheed Martin, with an expected cost for the entire mission of US$297 million. Its mission is to use spectrometers and a thermal imager to detect evidence of past or present water and ice, as well as study the planet's geology and radiation environment. The data Odyssey obtains is intended to help answer the question of whether life once existed on Mars and create a risk-assessment of the radiation that future astronauts on Mars might experience. It also acts as a relay for communications between the Curiosity rover, and previously the Mars Exploration Rovers and Phoenix lander, to Earth. The mission was named as a tribute to Arthur C. Clarke, evoking the name of his and Stanley Kubrick's 1968 film 2001: A Space Odyssey.

Odyssey was launched April 7, 2001, on a Delta II rocket from Cape Canaveral Air Force Station, and reached Mars orbit on October 24, 2001, at 02:30 UTC (October 23, 19:30 PDT, 22:30 EDT). As of March 2025, it is still collecting data, and is estimated to have enough propellant to function until the end of 2025. It currently holds the record for the longest-surviving continually active spacecraft in orbit around a planet other than Earth, ahead of the Pioneer Venus Orbiter (served 14 years) and the Mars Express (serving over 20 years), at 24 years and 8 days. As of October 2019^[update] it is in a polar orbit around Mars with a semi-major axis of about 3,800 km or 2,400 miles.

On May 28, 2002 (sol 210), NASA reported that Odyssey's GRS instrument had detected large amounts of hydrogen, a sign that there must be ice lying within a meter of the planet's surface, and proceeded to map the distribution of water below the shallow surface. The orbiter also discovered vast deposits of bulk water ice near the surface of equatorial regions.

Odyssey has also served as the primary means of communications for NASA's Mars surface explorers in the past decade, up to the Curiosity rover.

In August 2000, NASA solicited candidate names for the mission. Out of 200 names submitted, the committee chose Astrobiological Reconnaissance and Elemental Surveyor, abbreviated ARES (a tribute to Ares, the Greek god of war). Faced with criticism that this name was not very compelling, and too aggressive, the naming committee reconvened. The candidate name "2001 Mars Odyssey" had earlier been rejected because of copyright and trademark concerns. However, NASA e-mailed Arthur C. Clarke in Sri Lanka, who responded that he would be delighted to have the mission named after his books, and he had no objections. On September 20, NASA associate administrator Ed Weiler wrote to the associate administrator for public affairs recommending a name change from ARES to 2001 Mars Odyssey. Peggy Wilhide then approved the name change.

The three primary instruments Odyssey uses are the:

Mars Odyssey launched from Cape Canaveral on April 7, 2001, and arrived at Mars about 200 days later on October 24. Upon arrival, the spacecraft's main engine fired in order to decelerate, which allowed it to be captured into orbit around Mars. Odyssey then spent about 76 days aerobraking, using aerodynamic drag from the upper reaches of the Martian atmosphere to gradually slow down and reduce and circularize its orbit. By planning to use the atmosphere of Mars to slow the spacecraft in its orbit rather than firing its engine or thrusters, Odyssey did not need an additional 200 kilograms (440 lb) of propellant on board. This reduction in spacecraft weight allowed the mission to be launched on a Delta II 7925 launch vehicle, rather than a larger, more expensive launcher.

Aerobraking ended in January 2002, and Odyssey began its science mapping mission on February 19, 2002. Odyssey's original, nominal mission lasted until August 2004, but repeated mission extensions have kept the mission active.