The 2007 Coca-Cola 600 was the 12th stock car race of the 2007 NASCAR Nextel Cup Series and the event's 48th iteration. It was held on May 27, 2007, with 175,000 spectators in attendance, in Concord, North Carolina at Lowe's Motor Speedway, an intermediate track that holds NASCAR races. Casey Mears of the Hendrick Motorsports team won the 400-lap race after starting 16th. Joe Gibbs Racing's J. J. Yeley finished second and Kyle Petty of Petty Enterprises took third.

Before the race, Jeff Gordon led the Drivers' Championship by 231 points over his Hendrick Motorsports teammate Jimmie Johnson in second. Ryan Newman took the pole position by recording the fastest lap in the qualifying session and led the first ten laps before his Penske Racing South teammate Kurt Busch took over on lap 11. Busch led for 107 laps (the most of any driver in the race) before Brian Vickers took the lead after the first round of green-flag pit stops. Jimmie Johnson took the lead from Vickers on lap 184 and held it for 83 laps, battling for the position with Vickers and Matt Kenseth. Tony Stewart led at the race's final restart on lap 342 and held it until he made a pit stop for fuel 51 laps later. Mears took the lead after Dale Earnhardt Jr. and Denny Hamlin made similar pit stops, slowing to conserve fuel and winning. There were thirteen cautions and 29 lead changes among fifteen drivers during the race.

As of 2025^[update], the 2007 race is Mears' only win in the Nextel Cup Series, now known as the NASCAR Cup Series. After the race Gordon's lead in the Drivers' Championship was reduced to 132 points over Johnson because he crashed early in the race. Chevrolet increased its points advantage to 41 points ahead of Ford in the Manufacturers' Championship. Dodge moved further ahead of Toyota in the battle for third place, with 24 races remaining in the season.

The Coca-Cola 600 was the twelfth scheduled stock car race of the 2007 NASCAR Nextel Cup Series, out of 36, and the event's 48th iteration. It ran for 400 laps over a distance of 600 mi (970 km), and was held on May 27, 2007 in Concord, North Carolina at Lowe's Motor Speedway, now called Charlotte Motor Speedway, an intermediate track that holds NASCAR races. The standard track at Lowe's Motor Speedway is a four-turn, 1.5-mile (2.4 km)-long, quad-oval track. The track's turns are banked at 24 degrees; both the front stretch (the location of the finish line) and the back stretch (opposite the front) have a five-degree banking.

Before the race, Jeff Gordon led the Drivers' Championship with 1,881 points, with teammate Jimmie Johnson 231 points behind in second and Matt Kenseth a further 68 points behind in third. Denny Hamlin and Jeff Burton were fourth and fifth, and Tony Stewart, Kurt Busch, Kevin Harvick, Clint Bowyer, Carl Edwards, Kyle Busch and Jamie McMurray rounded out the top twelve. Chevrolet led the Manufacturers' Championship with 96 points, 35 points ahead of its rival Ford in second. Dodge with 52 points was 19 points ahead of Toyota in the battle for third place. The race's defending champion was Kasey Kahne.

The Coca-Cola 600 was conceived by race car driver Curtis Turner, who built the Charlotte Motor Speedway. It was first held in 1960 in an attempt by NASCAR to stage a Memorial Day weekend race to compete with the open-wheel Indianapolis 500; the two races were held together on the same day starting from 1974. The race is the longest in terms of distance on the NASCAR calendar, and is considered by several drivers to be one of the sport's most important races alongside the Daytona 500, the Brickyard 400 and the Southern 500. The long distance makes it the most physically demanding event in NASCAR, and teams adapt to changing track conditions because the race occurs between late afternoon and evening. It was known as the World 600 until 1984 when The Coca-Cola Company purchased the naming rights to the race and renamed it the Coca-Cola World 600 in 1985. It has been called the Coca-Cola 600 every year since 1986 except for 2002 when the name changed to Coca-Cola Racing Family 600.

In preparation for the race, NASCAR held several test sessions on May 7–8, 2007, to allow teams to prepare for the May races at Lowe's Motor Speedway. Sessions began at 2:00 p.m. Eastern Daylight Time (EDT) on May 7 and concluded at 9:00 p.m. On May 8, sessions started at 1:00 p.m. and stopped at 9:00 p.m. Eighty-two cars participated in the May 7 afternoon session; Martin Truex Jr. was quickest with a speed of 180.596 miles per hour (290.641 km/h) and David Stremme had the highest speed of the two days at 187.000 miles per hour (300.947 km/h) in the evening session. Towards the end of the second session, Hamlin lost control of his car and made heavy contact with an outside SAFER barrier; he was evaluated at the infield care center and was later released to continue testing. During the third session with eighty-four cars, Jeremy Mayfield had the fastest speed of 183.667 miles per hour (295.583 km/h) and Kurt Busch set the fastest speed of 185.644 miles per hour (298.765 km/h) in the fourth and final session held in the evening. David Gilliland spun but avoided contact with a wall.

There was one change of driver before the race. Starting at the 2007 Coca-Cola 600, 1988 NASCAR Winston Cup Series champion Bill Elliott returned to NASCAR on a part-time schedule for Wood Brothers Racing, replacing the team's regular driver Ken Schrader, who drove in the season's first eleven races. Elliott was eligible to use six Champion's Provisionals if the need arose. Elliott was looking forward to returning to racing: "I was pretty honored to get a call from the Wood Brothers to drive the 21 car. I've seen them struggle the last few weeks, being outside the top 35, and it breaks my heart to see them miss races. I hope I can get in the car, get us qualified well every week and see what we can make up in the points battle along the way."