The 2008 Setanta Sports Cup was the 4th staging of the Setanta Sports Cup, a cross-border cup competition featuring football clubs from the Republic of Ireland and Northern Ireland. The final was played on November 1, 2008, at Turners Cross in Cork.

Teams that progressed to the Semi-Finals are indicated in bold type.

Teams eliminated from the Setanta Sports Cup this stage are indicated in italics.

The draw for the semi-finals was made by drawing the winners of Group A against the runners-up of Group 2 and vice versa, with group winners having home advantage. Glentoran beat Drogheda United 1–0 in the first semi-final, which was played at United Park in Drogheda, while Cork City overcame Derry City by the same scoreline at the Brandywell Stadium in Derry.

The final took place on November 1, 2008, at Turners Cross stadium in front of 5,500, a sell out crowd, in Cork, where Cork City came from behind to beat Glentoran 2-1 and win the competition for the first time.