The 2010 BNP Paribas Open was a tennis tournament played at Indian Wells, California in March 2010. It was the 37th edition of the men's event (22nd for the women), also known as the Indian Wells Open, and is classified as an ATP World Tour Masters 1000 event on the 2010 ATP World Tour and a Premier Mandatory event on the 2010 WTA Tour. Both the men's and the women's events took place at the Indian Wells Tennis Garden in Indian Wells, California, United States from March 8 through March 21, 2010.

The year's tournament saw a couple of withdrawals; The women's side saw the draw without the top two rank players with World no. 2 Dinara Safina withdrawing with a recurring back problem and world no. 1 Serena Williams with sister Venus Williams continue their boycott from the tournament since Serena won the event in 2001. The men's side saw the withdrawals of Tommy Haas and Lleyton Hewitt due to hip surgeries. Juan Martín del Potro also withdrew due to a right wrist injury and Fernando González withdrew to aid his country Chile after an earthquake. Stanislas Wawrinka also withdrew due to the birth of his child. Mikhail Youzhny also withdrew.

Ivan Ljubičić defeated Andy Roddick, 7–6^(7–3), 7–6^(7–5)

Jelena Janković defeated Caroline Wozniacki, 6–2, 6–4

Marc López / Rafael Nadal defeated Daniel Nestor / Nenad Zimonjić, 7–6^(10–8), 6–3

Květa Peschke / Katarina Srebotnik defeated Nadia Petrova / Samantha Stosur, 6–4, 2–6, [10–5]

The following players received wildcards into the main draw:

The following player received entry using a protected ranking: