The First Stage of the 2011 Copa Santander Libertadores de América football tournament ran from January 25 to February 3, 2011 (first legs: January 25–27; second legs: February 1–3).
The twelve teams were drawn into six ties on November 25, 2010, in Asunción.[1]
Teams played in two-legged ties on a home-away basis. Each team earned 3 points for a win, 1 point for a draw, and 0 points for a loss. The following criteria were used for breaking ties on points:[2]
The six winners advanced to the second stage to join the 26 automatic qualifiers.
Team 1 played the second leg at home.
| Teams | Scores | Tie-breakers | |||||
|---|---|---|---|---|---|---|---|
| Team 1 | Points | Team 2 | 1st leg | 2nd leg | GD | AG | Pen. |
Deportes Tolima 
|
4:1 |  Corinthians
|
0–0 | 2–0 | — | — | — |
Chiapas 
|
6:0 |  Alianza Lima
|
2–0 | 2–0 | — | — | — |
Deportivo Petare 
|
1:4 |  Cerro Porteño
|
0–1 | 1–1 | — | — | — |
Unión Española 
|
4:1 |  Bolívar
|
1–0 | 0–0 | — | — | — |
Deportivo Quito 
|
3:3 |  Independiente
|
0–2 | 1–0 | −1:+1 | — | — |
| Grêmio
|
4:1 |  Liverpool
|
2–2 | 3–1 | — | — | — |
| Corinthians | 0–0 | Deportes Tolima |
|---|---|---|
| Report |
| Deportes Tolima | 2–0 | Corinthians |
|---|---|---|
Santoya  65'Medina 77' |
Report |
Deportes Tolima won on points 4–1.
| Chiapas | 2–0 | Alianza Lima |
|---|---|---|
| Pedroza 68' Salazar 74' |
Report |
Jaguares won on points 6–0.
| Cerro Porteño | 1–0 | Deportivo Petare |
|---|---|---|
| Nanni 70' |
Report |
| Deportivo Petare | 1–1 | Cerro Porteño |
|---|---|---|
| Guazá 13' |
Report | Nanni 34' |
Cerro Porteño won on points 4–1.
| Bolívar | 0–1 | Unión Española |
|---|---|---|
| Report | Cordero 17' |
Unión Española won on points 4–1.
| Independiente | 2–0 | Deportivo Quito |
|---|---|---|
| Defederico 49' Rodríguez 70' |
Report |
| Deportivo Quito | 1–0 | Independiente |
|---|---|---|
| Quiñónez 56' |
Report |
Tied on points 3–3, Independiente won on goal difference.
| Grêmio | 3–1 | Liverpool |
|---|---|---|
| André Lima 37' Vinícius Pacheco 57', 73' |
Report | Alfaro 34' |
Grêmio won on points 4–1.
