The 2015 Copa Sudamericana (Portuguese: Copa Sul-Americana 2015) was the 14th edition of the Copa Sudamericana, South America's secondary club football tournament organized by CONMEBOL.

Colombian team Santa Fe qualified to play in the 2016 Copa Libertadores, the 2016 Recopa Sudamericana, and the 2016 Suruga Bank Championship, after winning the final against Argentinian team Huracán 3–1 on penalties (0–0 on aggregate after extra time). River Plate were the defending champions, but were eliminated by Huracán in the semifinals.

The following 47 teams from the 10 CONMEBOL associations qualified for the tournament:

The entry stage is determined as follows:

The draw of the tournament was held on July 16, 2015, at the CONMEBOL Convention Centre in Luque, Paraguay.

For the first stage, the 32 teams were divided into two zones:

Teams which qualified for berths 1 were drawn against teams which qualified for berths 4, and teams which qualified for berths 2 were drawn against teams which qualified for berths 3, with the former hosting the second leg in both cases. Teams from the same association could not be drawn into the same tie.

For the second stage, the 30 teams, including the 16 winners of the first stage (eight from South Zone, eight from North Zone), whose identity was not known at the time of the draw, and the 14 teams which entered the second stage, were divided into three sections: