A mass shooting occurred on Danforth Avenue in the Greektown neighbourhood of Toronto, Ontario, Canada on the night of July 22, 2018. Faisal Hussain killed two people and wounded thirteen using a Smith & Wesson M&P .40-calibre handgun. He died by suicide after a shootout with Toronto Police Service (TPS) officers. Despite a year-long investigation, authorities were unable to determine a motive for the shooting. They noted that Hussain had mental health issues and a long-time obsession with violence.

Around 10:00 p.m. EDT on July 22, 2018, Faisal Hussain walked along Toronto's busy Danforth Avenue in the Greektown area of the city, randomly shooting pedestrians before opening fire on crowded restaurants. The incident began around Danforth and Logan Avenues at the Alexander the Great Parkette. At the parkette, Hussain appeared and shot seven people. Six of the seven people, including 18-year-old Reese Fallon, were shot at and near the parkette while one was shot several businesses away at the Mezes restaurant. Hussain proceeded to walk west along the north sidewalk of Danforth Avenue while firing rounds. Some witnesses described 10 to 15 blasts similar to firecrackers, while others reported hearing gunshots and seeing a man holding a gun. Hussain briefly stopped in front of the restaurant Pappas Grill and fired shots into the business, injuring one person. Hussain walked further west. Further along the Danforth at Chester Avenue, witnesses said they saw a man shooting from a sidewalk into another restaurant named Demetre's. At Demetre's, Hussain killed 10-year-old Julianna Kozis and injured two other victims. A cell phone video was also recorded and posted online depicting Hussain firing into Demetre's. At one point near Hampton Avenue, Hussain crossed the street from the north side to the south side to shoot into the Second Cup Coffee Co. business and at people along the south sidewalk. He wounded three people while at the front of the coffee shop. The shooter continued to walk westbound on Danforth Avenue and turned south into Bowden Street. In Bowden Street, Hussain turned into an alleyway and tried to move west. Hussain eventually walked into a dead-end and moved back east to leave the alleyway. In the alleyway, Hussain spared a man and also unsuccessfully tried shooting at another man. Hussain left the alleyway and ran north up Bowden Street. From there, witnesses said the shooter fired into the 7Numbers restaurant near Bowden Street where one victim was shot. While Hussain shot into the 7Numbers restaurant, a police cruiser drove north up Bowden Street and two police officers confronted Hussain. The shooter chose not to shoot certain people he encountered, telling one man, "Don't worry, I'm not going to shoot you." TPS officers responded to calls from witnesses and located the gunman on Bowden Street and initiated a shootout with the suspect as he ran west. The gunman ran back to Danforth Avenue where he was found dead from a self-afflicted gunshot wound to the head.

At the corner of Danforth and Logan avenues, police cordoned off an area from bystanders and detonated an unidentified package for undisclosed reasons.

18-year-old Reese Fallon and 10-year-old Julianna Kozis were killed in the attack.

Thirteen others suffered gunshot wounds, ranging in age from 17 to 59. Toronto Paramedic Services transported eight victims to trauma centres – including four people to St. Michael's Hospital, three to Sunnybrook Health Sciences Centre and one to The Hospital for Sick Children. St. Michael's reported it was treating five patients. Three of them underwent immediate lifesaving surgery after the shooting and the others were in serious but stable condition.

Two gunshot victims were treated at the nearby Michael Garron Hospital and were in stable condition. Five other patients were treated for issues related to the shooting, but were not shot.

The Special Investigations Unit (SIU) identified the perpetrator as 29-year-old Faisal Hussain.

Hussain was born to parents of Pakistani origin according to people who knew the family. In a public statement, Hussain's parents said that he was psychotic and depressed throughout his life. In 2010, Hussain told a friend that he was seeing a psychiatrist about these problems. A former teacher described him as "very disturbed" and recounted having to take him to a psychiatric facility after he started carving into his face with the blade of a pencil sharpener. Another former teacher called the police after Hussain allegedly said, without prompting, that "I want to kill someone." His family had been struggling through the death of his sister in a car accident and his brother's ongoing coma after an overdose or a stroke. According to a neighbour, Hussain was not religious and declined to participate in Friday prayers. According to his brother, Hussain had "started attending a mosque with his father, but did not seem that interested in religion."