 | This article relies largely or entirely on a single source. (September 2022) |
| 2021 IBG Prague Open | |
|---|---|
| Date | 23–29 August |
| Category | ATP Challenger Tour |
| Draw | 32S / 16D |
| Surface | Clay |
| Location | Prague, Czech Republic |
| Champions | |
| Singles | |
 Franco Agamenone | |
| Doubles | |
 Victor Vlad Cornea /  Petros Tsitsipas | |
The 2021 IBG Prague Open was a professional tennis tournament played on clay courts. It was part of the 2021 ATP Challenger Tour. It took place in Prague, Czech Republic, between 23 and 29 August 2021.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 RUS
|
Evgeny Karlovskiy | 290 | 1 |
 USA
|
Alexander Ritschard | 300 | 2 |
| RUS
|
Evgenii Tiurnev | 310 | 3 |
 FRA
|
Geoffrey Blancaneaux | 311 | 4 |
 CZE
|
Jonáš Forejtek | 315 | 5 |
 BEL
|
Michael Geerts | 319 | 6 |
| ROU
|
Filip Jianu | 320 | 7 |
 SRB
|
Miljan Zekić | 324 | 8 |
The following players received wildcards into the singles main draw:
Martin Krumich Andrew Paulson Daniel SiniakovThe following player received entry into the singles main draw using a protected ranking:
The following players received entry from the qualifying draw:
Franco Agamenone def. 
Ryan Peniston 6–3, 6–1. Victor Vlad Cornea / Petros Tsitsipas def. Martin Krumich / Andrew Paulson 6–3, 3–6, [10–8].
