2022 Mutua Madrid Open – Men's singles

The top eight seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.

The following are the seeded players based on the entry list per the ATP rankings as of 25 April 2022.^[5] The stated "rank" and "points before" are as of 2 May 2022.

As a result of special ranking adjustment rules due to the COVID-19 pandemic, players are defending the higher of (i) their points from the 2021 tournament or (ii) the remaining 50% of their points from the 2019 tournament. Those points were not mandatory and are included in the table below only if they counted towards the player's ranking as of 2 May 2022. Players who are not defending points from the 2021 or 2019 tournaments will instead have their 19th best result replaced by their points from the 2022 tournament.

Seed	Rank	Player	Points before	Points defending (or 19th best result)†	Points won	Points after	Status
1	1	Novak Djokovic	8,400	500	360	8,260	Semifinals lost to Carlos Alcaraz [7]
2	3	Alexander Zverev	7,420	1,000	600	7,020	Runner-up, lost to Carlos Alcaraz [7]
3	4	Rafael Nadal	6,435	180	180	6,435	Quarterfinals lost to Carlos Alcaraz [7]
4	5	Stefanos Tsitsipas	5,690	300	360	5,750	Semifinals lost to Alexander Zverev [2]
5	7	Casper Ruud	4,110	360	10	3,760	Second round lost to Dušan Lajović [Q]
6	8	Andrey Rublev	4,025	90	180	4,115	Quarterfinals lost to Stefanos Tsitsipas [4]
7	9	Carlos Alcaraz	3,818	45	1000	4,773	Champion, defeated Alexander Zverev [2]
8	10	Félix Auger-Aliassime	3,625	(45)	180	3,760	Quarterfinals lost to Alexander Zverev [2]
9	11	Cameron Norrie	3,335	(45)	90	3,380	Third round lost to Carlos Alcaraz [7]
10	12	Jannik Sinner	3,015	45	90	3,060	Third round lost to Félix Auger-Aliassime [8]
11	13	Taylor Fritz	3,010	(45)	0	2,965	Withdrew due to left foot injury
12	14	Hubert Hurkacz	3,008	58	180	3,130	Quarterfinals lost to Novak Djokovic [1]
13	15	Diego Schwartzman	2,805	(90)	45	2,760	Second round lost to Grigor Dimitrov
14	16	Denis Shapovalov	2,671	45	45	2,671	Second round lost to Andy Murray [WC]
15	17	Reilly Opelka	2,465	35	10	2,440	First round lost to Sebastian Korda
16	18	Pablo Carreño Busta	2,135	10	10	2,135	First round lost to Botic van de Zandschulp
17	19	Roberto Bautista Agut	1,993	45	45	1,993	Second round lost to Dan Evans

† This column shows either (a) the higher of the player's points from the 2021 tournament or 50% of his points from the 2019 tournament, or (b) his 19th best result (shown in brackets). Only ranking points counting towards the player's ranking as of May 2, 2022, are reflected in the column.

The following players would have been seeded, but withdrew before the tournament began.

Rank	Player	Points before	Points defending	Points after	Withdrawal reason
2	Daniil Medvedev	8,080	90	7,990	Hernia surgery
6	Matteo Berrettini	4,495	600	3,895	Right hand injury

Source:^[6]

1. Ugo Humbert

	First round							Qualifying competition
	1	Ugo Humbert	6	6
		Pablo Andújar	4	2
								1	Ugo Humbert	64	3
								13	Kwon Soon-woo	77	6
	WC	Shang Juncheng	7	3	4
	13	Kwon Soon-woo	5	6	6

	First round							Qualifying competition
	2	Alex Molčan	5	4
		Roberto Carballés Baena	7	6
									Roberto Carballés Baena	3	2
									Dušan Lajović	6	6
		Dušan Lajović	6	6
	12	Adrian Mannarino	4	2

	First round							Qualifying competition
	3	Francisco Cerúndolo	0	4
	WC	Alejandro Moro Cañas	6	6
								WC	Alejandro Moro Cañas	7	5	2
								10	Lorenzo Musetti	5	7	6
		Yoshihito Nishioka	5	3
	10	Lorenzo Musetti	7	6

	First round							Qualifying competition
	4	Márton Fucsovics	6	6
	WC	Daniel Mérida	4	3
								4	Márton Fucsovics	65	6	66
								11	Maxime Cressy	77	1	78
	WC	Daniel Rincón	3	4
	11	Maxime Cressy	6	6

	First round							Qualifying competition
	5	Mackenzie McDonald	6	3	6
		João Sousa	2	6	4
								5	Mackenzie McDonald	5	1
								Alt	Hugo Dellien	7	6
	Alt	Hugo Dellien	6	6
	14	Hugo Gaston	1	2

	First round							Qualifying competition
	6	Federico Coria	6	6
		Denis Kudla	2	2
								6	Federico Coria	77	4	2
								9	Benoît Paire	65	6	6
		Brandon Nakashima	0	6	3
	9	Benoît Paire	6	3	6

	First round							Qualifying competition
	7	Marcos Giron	3	5
	Alt	Alejandro Tabilo	6	7
								Alt	Alejandro Tabilo	4	4
								8	David Goffin	6	6
		Jiří Veselý	3	63
	8	David Goffin	6	77