The 2026 Missouri Senate election is to take place on Tuesday, November 3, 2026, with the primary election are to take place on Tuesday, August 4, 2026. Missouri voters selected state senators in the 17 even-numbered districts of the Senate to serve four-year terms.

The election coincides with United States national elections and Missouri state elections, including U.S. House, auditor, and Missouri House.

Following the previous election in 2024, Republicans held a 24-to-10-seat supermajority over Democrats. The balance of power remained unchanged, with Republicans keeping their supermajority of 24-to-10 over Democrats.

Italics denote an open seat held by the incumbent party; bold text denotes a gain for a party.

† - Incumbent term-limited or retiring

The 2nd district encompasses south central St. Charles County and includes O'Fallon, Lake St. Louis, Dardenne Prairie and Cottleville. The incumbent is Republican Nick Schroer.

The 4th district is split between southwestern St. Louis, including St. Louis Hills, North Hampton and Cheltenham, and St. Louis County, including Richmond Heights, Brentwood, Maplewood and part of Shrewsbury. The incumbent is Democrat Karla May, who is term-limited.

The 6th district is made up of Cole, Camden, Miller, Morgan and Moniteau counties, and includes the state capital of Jefferson City. The incumbent is Republican Mike Bernskoetter, who is term-limited.