2C-CN
2C-CN
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2C-CN

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2C-CN

2C-CN, also known as 4-cyano-2,5-dimethoxyphenethylamine, is a chemical compound of the phenethylamine and 2C families. It was not known to have been tested in humans and it is unknown whether it produces psychedelic effects. According to Daniel Trachsel however, 2C-CN was inactive at an oral dose of 10 mg, whereas an oral dose of 22 mg possibly produced threshold effects.

The drug is the 2C parent compound of potent serotonin 5-HT2A receptor agonists of the 25-NB family including 25CN-NBOH, 25CN-NBOMe, 25CN-NBF, and 25CN-NBMD, among others. 25CN-NBOH is notable in being one of the most selective serotonin 5-HT2A receptor agonists known. In addition, 25-NB derivatives of 2C-CN are known that act as β-arrestin-biased serotonin 5-HT2A receptor agonists.

2C-CN was first described in the scientific literature by 1984. It was briefly mentioned by Alexander Shulgin in his books PiHKAL (Phenethylamines I Have Known and Loved) (1991) and The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds (2011).

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