65537 is the integer after 65536 and before 65538.

65537 is the largest known prime number of the form ${\displaystyle 2^{2^{n}}+1}$ (${\displaystyle n=4}$), and is most likely the last one. Therefore, a regular polygon with 65537 sides is constructible with compass and unmarked straightedge. Johann Gustav Hermes gave the first explicit construction of this polygon. In number theory, primes of this form are known as Fermat primes, named after the mathematician Pierre de Fermat. The only known prime Fermat numbers are

${\displaystyle 2^{2^{0}}+1=2^{1}+1=3,}$

${\displaystyle 2^{2^{1}}+1=2^{2}+1=5,}$

${\displaystyle 2^{2^{2}}+1=2^{4}+1=17,}$

${\displaystyle 2^{2^{3}}+1=2^{8}+1=257,}$

${\displaystyle 2^{2^{4}}+1=2^{16}+1=65537.}$

In 1732, Leonhard Euler found that the next Fermat number is composite: