Around 923 CE, al-Razi returned to his hometown of Rayy. The reasons for his return are not entirely clear, but it may have been due to declining health or personal preferences.

In his later years, al-Razi suffered from progressive blindness. The exact cause of his blindness is unknown, but it may have been related to his extensive work with chemicals or to an underlying medical condition. Anecdotes say that he refused surgery to restore his vision, since the surgeon couldn't guarantee success, and al-Razi's sharp intellect and philosophical nature were not to be trifled with.

Abu Bakr al-Razi died in Rayy around the year 932 CE. He was approximately 60 years old. His death marked the end of a remarkable career that had a profound impact on the fields of medicine, philosophy, and science.