In ancient Roman religion, an aedicula (pl.: aediculae) is a small shrine, and in classical architecture refers to a niche covered by a pediment or entablature supported by a pair of columns and typically framing a statue. The early Christian ones sometimes contained funeral urns. Aediculae are also represented in art as a form of ornamentation.

The word aedicula is the diminutive of the Latin aedes, a temple building or dwelling place. The Latin word has been anglicised as aedicule and as edicule. Describing post-antique architecture, especially Renaissance architecture, aedicular forms may be described using the word tabernacle, as in tabernacle window.

Many aediculae were household shrines (lararia) that held small altars or statues of the Lares and Di Penates. The Lares were Roman deities protecting the house and the family household gods. The Penates were originally patron gods (really genii) of the storeroom, later becoming household gods guarding the entire house.

Other aediculae were small shrines within larger temples, usually set on a base, surmounted by a pediment and surrounded by columns. In ancient Roman architecture the aedicula has this representative function in the society. They are installed in public buildings like the triumphal arch, city gate, and thermae. The Library of Celsus in Ephesus (c. 2 AD) is a good example.

From the 4th century Christianization of the Roman Empire onwards such shrines, or the framework enclosing them, are often called by the Biblical term tabernacle, which becomes extended to any elaborated framework for a niche, window or picture.

In Gothic architecture, too, an aedicula or tabernacle is a structural framing device that gives importance to its contents, whether an inscribed plaque, a cult object, a bust or the like, by assuming the tectonic vocabulary of a little building that sets it apart from the wall against which it is placed. A tabernacle frame on a wall serves similar hieratic functions as a free-standing, three-dimensional architectural baldaquin or a ciborium over an altar.

In Late Gothic settings, altarpieces and devotional images were customarily crowned with gables and canopies supported by clustered-column piers, echoing in small the architecture of Gothic churches. Painted aediculae frame figures from sacred history in initial letters of illuminated manuscripts.

Classicizing architectonic structure and décor all'antica, in the "ancient [Roman] mode", became a fashionable way to frame a painted or bas-relief portrait, or protect an expensive and precious mirror during the High Renaissance; Italian precedents were imitated in France, then in Spain, England and Germany during the later 16th century.