The number of languages natively spoken in Africa is variously estimated (depending on the delineation of language vs. dialect) at between 1,250 and 2,100, and by some counts at over 3,000. Nigeria alone has over 500 languages (according to SIL Ethnologue), one of the greatest concentrations of linguistic diversity in the world. The languages of Africa belong to many distinct language families, among which the largest are:

There are several other small families and language isolates, as well as creoles and languages that have yet to be classified. In addition, Africa has a wide variety of sign languages, many of which are language isolates.

Around a hundred languages are widely used for interethnic communication. These include Arabic, Swahili, Amharic, Oromo, Igbo, Somali, Hausa, Manding, Fulani and Yoruba, which are spoken as a second (or non-first) language by millions of people. However that is changing because the is an awakening and such languages like Yoruba and Hausa languages are spoken as first language in various communities in Nigeria and Africa. Although many African languages are used on the radio, in newspapers and in primary-school education, and some of the larger ones are considered national languages, only a few are official at the national level. In Sub-Saharan Africa, most official languages at the national level tend to be colonial languages such as French, Portuguese, or English.

The African Union declared 2006 the "Year of African Languages".

Most languages natively spoken in Africa belong to one of the two large language families that dominate the continent: Afroasiatic, or Niger–Congo. Another hundred belong to smaller families such as Ubangian, Nilotic, Saharan, and the various families previously grouped under the umbrella term Khoisan. In addition, the languages of Africa include several unclassified languages and sign languages.

The earliest Afroasiatic languages are associated with the Capsian culture, the Saharan languages are linked with the Khartoum Mesolithic/Neolithic cultures. Niger-Congo languages are correlated with the west and central African hoe-based farming traditions and the Khoisan languages are matched with the south and southeastern Wilton culture.

Afroasiatic languages are spoken throughout North Africa, the Horn of Africa, Western Asia and parts of the Sahel. There are approximately 375 Afroasiatic languages spoken by over 400 million people. The main subfamilies of Afroasiatic are Berber, Chadic, Cushitic, Omotic, Egyptian and Semitic. The Afroasiatic Urheimat is uncertain. The family's most extensive branch, the Semitic languages (including Arabic, Amharic and Hebrew among others), is the only branch of Afroasiatic that is spoken outside Africa.

Some of the most widely spoken Afroasiatic languages include Arabic (a Semitic language, and a recent arrival from West Asia), Somali (Cushitic), Berber (Berber), Hausa (Chadic), Amharic (Semitic) and Oromo (Cushitic). Of the world's surviving language families, Afroasiatic has the longest written history, as both the Akkadian language of Mesopotamia and Ancient Egyptian are members.