Akuammine (vincamajoridine) is an indole alkaloid. It is the most abundant alkaloid found in the seeds from the tree Picralima nitida, commonly known as akuamma, comprising 0.56% of the dried powder. It has also been isolated from Vinca major. Akuammine is structurally related to yohimbine, mitragynine and more distantly Voacangine, all of which are alkaloid plant products with pharmacological properties.

Akuammine has antimalarial activity, and may be the primary constituent of P. nitida seeds responsible for this activity.

Akuammine is an opioid agonist with low affinity, selective for the mu-opioid receptor, when tested in vitro.