Alexandra Anna Daddario was born in New York City to Christina, a lawyer, and Richard Daddario, a prosecutor and former head of the New York City Police Department counterterrorism unit. She is of Italian, Irish, English, and Slovak descent.

Daddario began her acting career at the age of 15, playing the role of Laurie Lewis in the ABC daytime soap opera "All My Children". This marked the beginning of her journey in the entertainment industry.

Daddario's breakthrough came with the role of Annabeth Chase in the fantasy adventure film "Percy Jackson & the Olympians: The Lightning Thief". This role catapulted her into the limelight, showcasing her acting skills to a global audience.

Daddario took on diverse roles in both film and television, including "Texas Chainsaw 3D" and "True Detective". Her performances in these projects further solidified her status as a versatile actress.

Daddario starred in the disaster film "San Andreas", playing the role of Blake Gaines. This role cemented her status as a Hollywood leading lady, demonstrating her ability to connect with audiences in action-packed scenes.

Daddario starred in the film adaptation of "Baywatch", playing the role of Summer Quinn. This project, along with her subsequent roles in "The Layover" and "When We First Met", showcased her range in comedy and drama.

Daddario received critical acclaim for her role as Rachel Patton in the HBO satirical series "The White Lotus". Her performance earned her a nomination for the Primetime Emmy Award for Outstanding Supporting Actress in a Limited or Anthology Series or Movie.

Daddario began playing the lead role of Dr. Rowan Fielding in the AMC horror series "Mayfair Witches". This role marked another significant milestone in her career, showcasing her ability to excel in various genres.