The fifth season of the American horror anthology television series American Horror Story, subtitled Hotel, is centered around the mysterious Hotel Cortez in Los Angeles, the scene of disturbing and paranormal events, overseen by its enigmatic staff. The location is loosely based on the Cecil Hotel, marked by deaths and tragedies. The ensemble cast includes Wes Bentley, Chloë Sevigny, Sarah Paulson, Evan Peters, Matt Bomer, Denis O'Hare, Cheyenne Jackson, Angela Bassett, Kathy Bates, and Lady Gaga, with all returning from previous seasons, except newcomers Jackson and Gaga. Hotel marks the first season to not feature cast mainstays Jessica Lange and Frances Conroy. Breaking from the anthological format, the season is connected to Murder House and Coven.

Created by Ryan Murphy and Brad Falchuk for the cable network FX, the series is produced by 20th Century Fox Television. Hotel broadcast between October 7, 2015, to January 13, 2016, consisting of 12 episodes, despite initially reported to consists of 13 episodes. The season was confirmed in October 2014, with the subtitle Hotel announced in February 2015. As stated by Murphy and Falchuk, Hotel is thematically darker than previous installments and was inspired by old hotel horror films and actual hotels situated in downtown Los Angeles with a reputation for sinister events. The cycle also marks a return to filming in Los Angeles, where the first two seasons were shot. Hotel features one of the most expansive sets in American Horror Story history, with production designer Mark Worthington building two stories on a soundstage, along with a working elevator and stairway. In July 2015, FX launched a marketing campaign for the series, with most trailers and teasers touting Gaga's involvement.

Hotel garnered eight Emmy Award nominations, including two acting nominations for Paulson and Bates. However, it was the first time that a season of American Horror Story was not nominated for Outstanding Limited Series. In addition, Gaga won the Golden Globe Award for Best Actress – Mini-Series or Television Film, while Hotel received a nomination for Best Mini-Series or Television Film.

On October 13, 2014, FX renewed the series for a fifth season for an October 2015 premiere. Network president John Landgraf stated that the season would necessitate a "huge reinvention" for the series. The season's subtitle was confirmed as Hotel in February 2015. The theme and Gaga's involvement were hinted in the previous installment as an image of a top hat, an arcane clue alluding to the 1935 screwball musical comedy film Top Hat, which is set in a hotel and features a song called "Cheek to Cheek", also the title of Gaga's duet album with Tony Bennett. Co-creator Ryan Murphy explained that the casting included a number of actors and singers, but would be a much darker season compared to the previous ones. Inspiration came from old hotel horror films and actual hotels situated in downtown Los Angeles, with horrific reputations. This included The Cecil, where the death of 21-year-old Canadian student Elisa Lam occurred. Murphy had watched a surveillance video of Lam in the hotel, in which she displayed erratic behavior just hours prior to her supposed death. It was around this time that the writing for Hotel was conceptualized, which included Murphy's personal phobia and fears, a fear that had not been explored since the first season.

The upcoming season that we're doing is much more horror-based; it's much more dark. It's about a theme and an idea that's very close to my heart that I've always wanted to do that's a little bloodier and grislier, I think, than anything that we've done before; it's straight horror this year. Murder House, I thought, was a very primal season because everybody's great fear is about the bogeyman under the bed in their house, and this feels similar to me in that when you check into a hotel, there are certain things beyond your control... Other people have the keys to your room; they can come in there. You're not exactly safe, it's a very unsettling idea.

Murphy and some of the cast appeared at the 2015 Comic-Con International and revealed further information about the series. "[Angela Bassett, Kathy Bates, Matt Bomer, Sarah Paulson, and Evan Peters] are bad boys and girls this time." Regarding the season having no primary character, Murphy confessed that "the thing that's different about the season is that before we've always been very driven by the Jessica Lange character. She was always the lead character... This year, it's a true ensemble, and I think we have more male parts and more male stories. The Wes Bentley part is really big; the Matt Bomer part is really big; Evan Peters and Finn Wittrock are really big. [But] that's not to say that the women aren't either."

Co-creator Brad Falchuk explained that like the first and second season of the series, Hotel would explore the "trapped" horror trope, though the actions would not be limited to just within the premises. "This season, the horror is sneaking out of the hotel," he added explaining that the plot would revolve around the hotel in the center, with a more noir like ambience. Named as Hotel Cortez, the titular structure was built by James March in 1930, who was created as a rich and charming but deeply psychotic character. The season features two tormentors, The Ten Commandments Killer, who is inspired by biblical teachings, and The Addiction Demon, who wields a drill bit dildo. They are in the vein of previous seasons' Bloody Face and Rubber Man, respectively. The Halloween episode, "Devil's Night", features a dinner with "the biggest serial killers of all time", including Wuornos and John Wayne Gacy.

The hotel's two-story lobby set, along with a working elevator, was constructed over seven weeks. While no particular hotel served as inspiration, production designer Mark Worthington was influenced by Timothy Pflueger and William Van Alen when selecting patterns and schemes, stating, "Tonally, I thought Art Deco would make sense for the horror genre because it can be dark and spiky and odd and the composition is strange. It's beautiful, but it isn't necessarily inviting." The hotel consists of complicated structures housing March's murderous fantasies with dead ends, secret rooms and includes plot lines corresponding to it. A painting of Hernán Cortés, after whom the establishment is named, hangs in the reception area. Worthington and his team had a hand in creating even the smallest details, such as hotel symbols for the light fixtures, bar coasters, and a venus flytrap column carving reflecting the nature of Gaga's character. The staircase was structured in such a way as to not pull focus from the elevator, which will serve as a prime location. The exterior of the set was inspired by the James Oviatt Building in Downtown Los Angeles, while the interior decorations were modeled from the Cicada restaurant situated inside the Oviatt.