Following his master's, Bose was invited to join the faculty of MIT as an Assistant Professor of Electrical Engineering. He taught courses on circuit theory and developed new teaching methods that emphasized problem-solving and critical thinking.

Throughout his tenure at MIT, Bose taught various courses in electrical engineering and conducted groundbreaking research in acoustics, psychoacoustics, and nonlinear systems. He was known for his engaging teaching style and his ability to inspire students.

Bose was a dedicated mentor to numerous students at MIT, providing guidance and support for their academic and professional pursuits. He fostered a culture of innovation and encouraged his students to pursue their passions. Some of his students went on to become successful entrepreneurs and leaders in the technology industry.

Even in his later years, Bose remained actively involved in research at MIT. He continued to explore new frontiers in acoustics and signal processing, pushing the boundaries of knowledge in these fields.