Andromeda (formally titled Gene Roddenberry's Andromeda) is a space opera television series, based on unused material by Gene Roddenberry, developed by Robert Hewitt Wolfe, and produced by Roddenberry's widow, Majel Barrett. The series follows Kevin Sorbo as Captain Dylan Hunt of the Systems Commonwealth, an intergalactic government that presided over an extended period of peace and prosperity until its destruction from a rebellion led by the warmongering Nietzscheans and parasitic Magog. The series premiered on October 2, 2000, and ended on May 13, 2005.

Andromeda was filmed in Vancouver, British Columbia, Canada and produced by Andromeda Productions, Tribune Entertainment, Fireworks Entertainment and MBR Productions. In Canada, the show aired on Global Television Network (Fireworks' parent company) and ran in first-run broadcast syndication in the United States.

Andromeda is one of two television series (alongside Earth: Final Conflict) produced after Roddenberry's death based on concepts he had created as early as the 1960s and 1970s; Roddenberry died in 1991, nine years prior to the series premiere. The name Dylan Hunt had previously been used for the hero of two television pilots Roddenberry had produced in the mid-1970s – Genesis II and Planet Earth – all of which shared a similar dystopian post-apocalyptic premise.

Thousands of years in the future, the Systems Commonwealth is a constitutional monarchy spanning the Milky Way, Triangulum, and Andromeda galaxies, with the capital of Tarn-Vedra near Andromeda's core. The Commonwealth is at war with the Magog, a parasitic humanoid species spreading across the galaxies. Peace talks led the Commonwealth to cede a key world to the Magog, that of the Nietzscheans; in response, the Nietzscheans secretly attempted to usurp control of the Commonwealth.

Dylan Hunt is the captain of the Commonwealth starship Andromeda Ascendant. Its computer is a powerful artificial intelligence which Dylan has nicknamed "Andromeda" or "Rommie". Caught in a surprise attack in the first engagement of the Nietzschean uprising, the Andromeda is crippled, prompting Dylan to order the crew to evacuate. During the attack, Dylan's Nietzschean first officer, Gaheris Rhade, betrays Dylan and attempts to kill him. Dylan kills Gaheris as Andromeda is caught at the edge of the event horizon of a black hole, freezing both in time.

303 years later, in CY 10087 (approx 5167 AD), the Andromeda is pulled from the event horizon by the crew of the salvage ship Eureka Maru, captained by con-artist and expert pilot Beka Valentine, super-genius engineer Seamus Zelazny Harper, doctor and alien of unknown origin Trance Gemini, and pacifist Magog Rev Bem (the salvage crew's beneficiary also secretly brings Nietzschean mercenary Tyr Anasazi). The Systems Commonwealth has fallen, and the era known as The Long Night has begun. Hunt recruits the crew to join him in restoring the Systems Commonwealth and to "rekindle the light of civilization".

Slipstream is the primary mode of travel for ships in the Andromeda universe, and the only known method of traveling faster than the speed of light. The Vedran discovery of the slipstream was instrumental in the formation of their interstellar empire, which became the precursor of the Systems Commonwealth.

Slipstream cannot be navigated by AIs (they only have a 50% chance of choosing the correct path). Only organic pilots can "sense" a way to their destination (they have a 99% chance of choosing the correct path), and although AIs are fitted on all large ships, they always require an organic pilot for interstellar travel. It is implied that the process of choosing a path is what makes it the correct one.