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Angiofibroma
Angiofibroma, Hematoxylin and eosin stain, magnification ×10.
SpecialtyOncology Edit this on Wikidata
SymptomsItchiness and sometimes bleeding.[1]
ComplicationsFacial disfigurement and stigmatization.[1]
CausesLocal overgrowth of collagen, fibroblasts, and blood vessels.[1]
Risk factorsTuberous sclerosis, Birt-Hogg-Dubé syndrome, and Multiple endocrine neoplasia type 1.[1]
Diagnostic methodSkin biopsy.[1]
Differential diagnosisIntradermal melanocytic naevus, Acne, Basal cell carcinoma, Viral warts, Subungual exostosis, Molluscum contagiosum, and Anogenital warts.[1]
TreatmentExcision, Dermabrasion, Using lasers, electrical, and radiofrequency devices, Cryotherapy, Topical podophyllotoxin, Topical rapamycin, and Topical beta-blockers.[1]

Angiofibroma (AGF) is a descriptive term for a wide range of benign skin or mucous membrane (i.e. the outer membrane lining body cavities such as the mouth and nose) lesions in which individuals have:

  1. benign papules, i.e. pinhead-sized elevations that lack visible evidence of containing fluid;
  2. nodules, i.e. small firm lumps usually > 1 mm in diameter; and/or
  3. tumors, i.e. masses often regarded as ~8 mm or larger.

Diagnosis

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AGF lesions share common macroscopic (i.e. gross) and microscopic appearances. Grossly, AGF lesions consist of multiple papules, one or more skin-colored to erythematous, dome-shaped nodules, or usually just a single tumor. Microscopically, they consist of spindle-shaped and stellate-shaped cells centered around dilated and thin-walled blood vessels in a background of coarse bundles of collagen (i.e. the main fibrous component of connective tissue).[2] Angiofibromas have been divided into different types but commonly a specific type was given multiple and very different names in different studies.[2]

Cutaneous angiofibroma

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These papule, nodule, and/or tumor lesions occur on the: 1) face and are typically termed fibrous papules; 2) penis and are typically termed pearly penile papules; and 3) underneath a fingernail or toenail and are typically termed periungual angiofibromas. Some of these cutaneous AGF lesions occur in individuals with one or more of 3 different genetic diseases: tuberous sclerosis, multiple endocrine neoplasia type 1, and Birt-Hogg-Dube syndrome.[3] The following are examples of these cutaneous angiofibromas and their alternate names.

Fibrous papules

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Main article: Adenoma sebaceum

Fibrous papules are also termed facial angiofibromas and were formerly and incorrectly termed adenoma sebaceum (fibrous papules are unrelated to sebaceous glands[4]). They develop in up to 8% of the general adult population and occur as 1 to 3[5] pink to red,[4] dome-shaped papules in the central areas of the face, nose, and/or lips.[6] About 75% of individuals with tuberous sclerosis present with fibrous papules in their infancy or early childhood; when associated with this rare disease, the lesions often occur as multiple papules[5] in symmetrical, butterfly-shaped patterns over both cheeks and the nose.[7] Fibrous papules also occur in individuals with multiple endocrine neoplasia type 1 (a study done in Japan found that 43% of individuals with this genetic disease bore facial angiofibromas)[8] and, uncommonly, in individuals with Birt-Hogg-Dube syndrome.[9]

Pearly penile papules

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Main article: Pearly penile papules

Pearly penile papules are also termed papillae coronae glandis and hirsutoid papillomas. The condition of having such papules or papillae is called hirsuties papillaris coronae glandis or papillomatosis coronae glandis or papillomatosis coronae penis.[10] These lesions develop in up to 30% of males during their puberty or, less commonly, early adulthood. They typically occur as numerous white-colored to skin-colored papules located circumferentially around the corona of the penis or, less commonly, the ventromedial aspect of the corona near the penis's frenulum.[11] (Vestibular papillomatosis, also named hirsutoid vulvar papillomas, vulvar squamous papillomatosis, micropapillomatosis labialis, and squamous vestibular micropapilloma, is the female equivalent of pearly penile papules in men.[12] It has not been formally termed an angiofibroma.)

Periungual angiofibromas

[edit]
Main article: Koenen's tumor

Periungual angiofibromas are also termed Koenen's tumors, periungual fibromas, and subungual fibromas.[13] In addition, these tumors were formerly regarded as a type of acral angiofibroma (see below description).[14] These lesions present as multiple nodules or tumors under multiple finger and/or toe nails of individuals with tuberous sclerosis[4] or in one case the Birt-Hogg-Dube syndrome.[15] Periungual angiofibromas have also been reported to occur in individuals that do not have these genetic diseases.[16] Periungual angiofibromas tumors can be highly mutilating finger/toe-nail lesions.[4]

Oral fibromas

[edit]
Main article: Oral fibroma

Oral fibromas are also termed irritation fibromas, focal fibrous hyperplasia, and traumatic fibromas.[17] These lesions are nodules that occur on the buccal mucosa (i.e. mucous membranes lining the cheeks and back of the lips) or lateral tongue.[18] They may be irritating or asymptomatic and are the most common tumor-like lesions in the oral cavity. Oral fibromas are not neoplasms; they are hyperplastic (i.e. overgrowth) reactions of fibrous tissue to local trauma or chronic irritation.[19]

Nasopharyngeal angiofibromas

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Main article: Nasopharyngeal angiofibroma

Nasopharyngeal angiofibromas, also termed juvenile nasopharyngeal angiofibromas, fibromatous hamartomas, or angiofibromatous hamartoma of the nasal cavity, are large benign tumors (average size 5.9 cm in one study) that develop almost exclusively in males aged 9 to 36 years old. They commonly arise in the nasopharynx (i.e. upper part of the throat that lies behind the nose) and typically have attachments to the sphenopalatine foramen, clivus, and/or root of the pterygoid processes of the sphenoid bone. These tumors may expand into various other nearby structures including the cranial cavity.[20] Nasopharyngeal angiofibromas are highly vascularized tumors consisting of fibroblasts (i.e. connective tissue cells) in a dense collagen matrix (i.e. tissue background). Studies have suggested that these tumors are due to the expression of male sex hormones (i.e. androgens and progesterones), genetic factors, molecular alterations (i.e. changes in the normal characteristics of cells that lead to abnormal cell growth), and/or human papillomavirus infection.[21]

Angiofibroma of soft tissue

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Main article: Angiofibroma of soft tissue

Angiofibroma of soft tissue is also named angiofibroma, not otherwise specified, by the World Health Organization, 2020. The Organization also classified these lesions as in the category of benign fibroblastic and myofibroblastic tumors.[22] These tumors more often afflict females,[23] typically occur in adults (median age 49 years), have a median size of ~3.5 cm, and develop in a leg near to, and may invade, a large joint. Less uncommonly, they occur in the back, abdominal wall, pelvic cavity, or breast. Angiofibroma of soft tissue tumors consist of uniform, bland, spindle-shaped cells and a prominent vascular network consisting of small thin-walled branching blood vessels in a variably collagenous tissue background. Its tumor cells contain an AHRR-NCOA2 fusion gene in 60% to 80% of cases and a GTF2I-NCOA2 or GAB1-ABL1 fusion gene in rare cases.[24]

Cellular angiofibroma

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Main article: Cellular angiofibroma

Cellular angiofibroma is usually a small, slow-growing tumor arising in the vulva-vaginal areas of adult woman and the inguinal-scrotal areas of adult men although some of these tumors, especially in men, can grow up to 25 cm. Affected men are usually older (7th decade) than women (5th decade).[25] Less commonly. cellular angiofibromas have occurred in various other superficial soft tissue areas throughout the body.[26] These tumors are edematous (i.e. abnormally swollen with fluid), highly vascular, spindle-shaped cell lesions with a variable amount of fibrous stroma.[25] In 2020, the World Health Organization classified cellular angiofibroma tumors in the category of benign fibroblastic/myofibroblastic tumors.[22] The tumor cells in these lesions contain chromosome and gene abnormalities including a loss of one of the two RB1 genes. It has been suggested that the loss of this gene contributes to the development of cellular angiofibroma tumors.[27]

Acral angiofibromas

[edit]
Main article: Superficial acral fibromyxoma

Acral angiofibromas are also termed superficial acral fibromyxomas, digital fibromyxomas, acquired digital fibrokeratomas, acquired periungual fibrokeratomas, garlic clove fibromas,[28] digital fibromas, and cellular digital fibromas.[14] At one time, periungual angiofibromas were regarded as a type of acral angiofibroma (see above description).[14] Acral refers to distal sites of the ears, nose, hands, fingers, feet, and toes. Acral angifibromeae occur primarily in areas close to the nails of fingers and toes (~80% of cases)[28] or, less commonly, palms of the hands or soles of the feet.[14] The tissues of this tumor consists of bland spindle-shaped and star-shaped cells within a collagen fiber-rich stroma containing prominent blood vessels and mast cells.[28]

  • Photos
  • Glans penis with Hirsuties papillaris penis. Papules are common on uncircumcised penises.
    Glans penis with Hirsuties papillaris penis. Papules are common on uncircumcised penises.
  • Koenen tumor in patient with tuberous sclerosis complex.
    Koenen tumor in patient with tuberous sclerosis complex.
  • Photo of irritation fibroma on the labial mucosa.
    Photo of irritation fibroma on the labial mucosa.
  • High magnification micrograph of a nasopharyngeal angiofibroma.
    High magnification micrograph of a nasopharyngeal angiofibroma.
  • Adenoma sebaceum. Multiple wart-like, waxy lumps consisting of angiomatous and fibrous tissue associated with tuberous sclerosis.
    Adenoma sebaceum. Multiple wart-like, waxy lumps consisting of angiomatous and fibrous tissue associated with tuberous sclerosis.

See also

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References

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Revisions and contributorsEdit on WikipediaRead on Wikipedia

Angiofibroma

View on Grokipedia
from Grokipedia
An angiofibroma is a benign characterized by the proliferation of fibroblasts and thin-walled blood vessels within a fibrous stroma, typically presenting as a firm, reddish or flesh-colored growth. These tumors arise in various anatomical sites, including the skin, nasopharynx, , and soft tissues, and are generally nonmetastasizing, though certain subtypes exhibit locally invasive behavior. The most common form, cutaneous angiofibroma, manifests as small papules or nodules on the face, often associated with genetic syndromes such as tuberous sclerosis complex (TSC), where mutations in the TSC1 or TSC2 genes lead to pathway dysregulation and formation. In TSC, facial angiofibromas appear symmetrically on the cheeks and during childhood or adolescence, affecting up to 75% of patients, while periungual variants occur around the nails in 30-60% of cases. Diagnosis relies on clinical examination and showing stellate fibroblasts amid vascular channels, with treatment options including topical inhibitors like or to manage cosmetic and symptomatic issues. Another notable subtype is juvenile nasopharyngeal angiofibroma (JNA), a rare, highly vascular tumor originating near the sphenopalatine foramen in the posterior nasal cavity, almost exclusively affecting adolescent males aged 9-25 due to possible androgen-driven growth. It accounts for 0.05-0.5% of head and neck tumors, with an incidence of 1 in 150,000-1,500,000, and presents with unilateral epistaxis, nasal obstruction, and potential extension to cause facial deformity or cranial nerve deficits. Pathologically, JNA features angiomatous stroma with irregular vessels lacking smooth muscle, supplied by branches of the external carotid artery; preoperative embolization is often used to reduce bleeding risk before surgical resection, the primary treatment, though recurrence rates reach 30-38%. Angiofibroma of , recognized in the 2020 WHO classification of tumors, is a fibroblastic with a prominent branching vascular network, typically occurring as a slow-growing, well-circumscribed mass in the periarticular regions of the lower extremities in adults, with a slight female predominance and peak incidence in the sixth decade. Histologically, it comprises uniform spindle cells in a collagenous or myxoid background without , often harboring NCOA2 rearrangements; shows enhancing masses on MRI, and complete surgical excision is curative, with rare local recurrences but no metastatic potential.

Overview

Definition

An angiofibroma is a benign characterized by a proliferation of fibrous interspersed with dilated blood vessels, typically arising from fibroblast-like stromal cells and vascular lined by flattened endothelial cells. This fibrovascular composition results in tumors that are usually firm and reddish, reflecting the prominent vascular component within a fibrous stroma. The term "angiofibroma" derives from the Greek prefix "angio-" denoting blood vessels and "" referring to a fibrous tumor, highlighting its dual histological features of vascular and fibroblastic elements. Although ancient descriptions of similar nasal growths date back to in the , the specific nomenclature "angiofibroma" was first applied to the nasal variant by Walter Friedberg in 1940. Angiofibromas are generally benign with low recurrence rates following excision, though certain subtypes, such as cellular angiofibroma, exhibit rare potential for sarcomatous transformation into . These tumors can manifest in diverse anatomical sites, including cutaneous, mucosal, and locations.

Classification

Angiofibromas are primarily classified by anatomical site, encompassing cutaneous, mucosal/oral, nasopharyngeal, , and genital/acral locations, which reflect their diverse clinical presentations and origins. Cutaneous angiofibromas typically arise in the of the face or extremities, while mucosal and oral variants involve the oral cavity or other mucous membranes. Nasopharyngeal angiofibromas, often juvenile in nature, originate in the posterior , and angiofibromas occur in subcutaneous or deeper tissues, frequently near joints. Genital and acral forms, such as those around the nails or in the vulvovaginal and inguinal regions, represent site-specific manifestations that may overlap with syndromic contexts. Histologically, angiofibromas exhibit variants ranging from simple to cellular types, distinguished by the degree of cellularity and stromal composition. Simple angiofibromas feature a fibrous stroma with scattered thin-walled blood vessels and bland spindle cells arranged in collagen bundles, lacking significant proliferation. In contrast, cellular variants display increased cellularity with prominent spindle cell proliferation, forming fascicles or haphazard patterns amid a vascular network, though without marked atypia or mitoses. These differences aid in differentiating benign from potentially more aggressive-appearing lesions, though all remain non-malignant. Angiofibromas are further grouped by clinical association into syndromic and sporadic categories, influencing diagnostic and management approaches. Syndromic angiofibromas, such as facial and periungual types linked to tuberous sclerosis complex (TSC), arise due to germline mutations in TSC1 or TSC2 genes and serve as major diagnostic criteria when multiple lesions are present. Sporadic forms, lacking genetic syndrome association, occur as isolated lesions like solitary fibrous papules on the face. This distinction highlights the role of underlying genetic factors in syndromic cases versus idiopathic development in sporadic ones. In the (WHO) classification of and bone tumors, angiofibroma of is recognized as a distinct benign fibroblastic , characterized by uniform spindle cells, myxoid or collagenous stroma, and arborizing thin-walled vessels, often harboring NCOA2 gene rearrangements. As of 2025, this entity remains established under the 2020 WHO framework without major revisions, emphasizing its well-circumscribed nature and favorable prognosis following excision.

Epidemiology

Incidence and demographics

Angiofibromas represent a heterogeneous group of rare benign neoplasms, with cutaneous variants comprising the most frequently diagnosed subtype in . While population-based incidence rates for sporadic cutaneous angiofibromas remain incompletely documented, they are considered relatively common dermal lesions compared to other forms. In particular, (JNA) is exceptionally rare, with an estimated annual incidence of 1:150,000 individuals and accounting for 0.05% to 0.5% of all head and neck tumors. Age at presentation varies significantly by subtype. Cutaneous angiofibromas, such as fibrous papules, predominantly affect adults in their 30s to 50s, with a reported mean diagnostic age of 37.7 years. JNA, by contrast, occurs almost exclusively during , with peak onset between 10 and 20 years of age and a mean presentation around 15 years. Demographic patterns reveal a strong gender skew for certain types. JNA demonstrates a pronounced predominance, affecting s in 90% to 95% of cases, potentially linked to hormonal influences during . Cutaneous angiofibromas show no substantial gender disparity. Ethnic predispositions are not markedly evident across angiofibroma subtypes. Angiofibroma of is a rare entity, with reported cases spanning ages 6 to 86 years ( 49 years) and a predominance (approximately 2:1 -to-male ). It most commonly presents as a slow-growing mass in the periarticular s of the lower extremities in adults. Population-based incidence rates are not established due to its rarity. Globally, angiofibroma incidence has remained stable, but enhanced detection through advanced imaging modalities like computed tomography and since the early 2000s has led to increased reporting and earlier identification. Facial angiofibromas are notably prevalent in complex, occurring in 64% to 90% of affected patients.

Associated conditions

Angiofibromas are prominently associated with tuberous sclerosis complex (TSC), an autosomal dominant neurocutaneous disorder caused by germline mutations in the TSC1 or TSC2 genes, which encode hamartin and tuberin, respectively. In TSC, facial angiofibromas—often appearing as multiple reddish papules on the cheeks, nose, and chin—are a major diagnostic criterion and occur in approximately 75% to 90% of affected individuals, typically emerging in childhood or adolescence. Periungual fibromas, which are nail-fold variants of angiofibromas, also represent a major feature of TSC and further support the syndromic diagnosis when present alongside other manifestations like hypomelanotic macules or cortical tubers. Birt-Hogg-Dubé syndrome (BHDS), another autosomal dominant genodermatosis resulting from mutations in the FLCN gene encoding folliculin, features skin lesions that can mimic angiofibromas, particularly multiple facial papules histologically consistent with fibrofolliculomas or trichodiscomas. Although fibrofolliculomas are the hallmark cutaneous finding in BHDS, reports document rare presentations of angiofibroma-like lesions as an initial manifestation, often prompting from TSC due to overlapping facial involvement. These associations extend to increased risks of renal tumors and pulmonary cysts in BHDS, highlighting the need for systemic evaluation. For juvenile nasopharyngeal angiofibroma (JNA), a benign but locally aggressive predominantly affecting adolescent males, hormonal influences are implicated through expression of receptors in tumor tissue, suggesting potential androgen-dependent growth that aligns with its pubertal onset and sex predilection. This has historically supported adjunctive hormonal therapies, though evidence remains mixed regarding direct causality. In contrast, most sporadic cutaneous angiofibromas lack strong syndromic or hormonal links, arising de novo without identifiable genetic or endocrine drivers. The presence of multiple facial or periungual angiofibromas raises suspicion for underlying TSC, warranting prompt for TSC1 and TSC2 variants to confirm and guide surveillance for associated complications like seizures or renal angiomyolipomas. According to the updated international criteria (), major diagnostic features include three or more hypomelanotic macules (at least 5 mm in diameter), three or more facial angiofibromas or a fibrous cephalic plaque, two or more ungual fibromas, and one or more patches (among others); definite TSC requires two or more major features, or one major feature plus two or more minor features, or identification of a pathogenic variant in TSC1 or TSC2, emphasizing early molecular confirmation in suspicious cases. For BHDS-suspected presentations, FLCN sequencing is recommended if angiofibroma-like lesions accompany pulmonary or renal findings.

Pathophysiology

Etiology and risk factors

The etiology of angiofibromas remains incompletely understood, but genetic factors play a prominent role in syndromic cases, particularly those associated with tuberous sclerosis complex (TSC). In TSC patients, cutaneous facial angiofibromas arise from somatic second-hit mutations in the TSC1 or TSC2 tumor suppressor genes, which disrupt the signaling pathway and promote hamartomatous growth; ultraviolet (UV) radiation from sun exposure induces these mutations, leading to in affected skin cells. These mutations are not germline but occur postzygotically, explaining the focal distribution of lesions in TSC-affected individuals. For juvenile (JNA), genetic alterations include frequent numerical aberrations in and somatic mutations in the Y-chromosome male-specific region, alongside hormonal influences that contribute to its development. Hormonal influences contribute to the development of specific angiofibroma subtypes, notably JNA, which exhibits androgen-dependent growth patterns linked to in adolescent males. Elevated free testosterone levels and expression of receptors in tumor tissue support this hormonal sensitivity, though the precise mechanism remains unclear. In cellular angiofibromas, particularly vulvovaginal variants in women, and positivity is frequently observed, suggesting a potential role for sex signaling in tumorigenesis, especially during menopausal transitions; these tumors also feature characteristic monoallelic loss of the RB1 gene at chromosome 13q14. Oral fibromas, by contrast, are triggered by local trauma or chronic irritation, such as from , cheek biting, or food impaction, resulting in reactive fibrous rather than neoplastic proliferation. Environmental risk factors include chronic sun exposure for facial fibrous papules (a form of cutaneous angiofibroma), where cumulative UV damage promotes fibrovascular proliferation in sun-exposed areas like the . No confirmed viral or infectious etiologies have been identified for angiofibromas; studies have ruled out associations with Epstein-Barr virus and human herpesvirus-8 in JNA, and broader investigations support a non-infectious across subtypes.

Histopathology

Angiofibromas are characterized microscopically by a dermal or proliferation of bland spindle-shaped fibroblasts embedded in a collagenous stroma, accompanied by a prominent network of thin-walled, branching blood vessels. The stromal component often includes variable amounts of bundles and myxoid matrix, with occasional stellate or multinucleate cells, particularly in fibrous variants. Mitotic activity is rare, and the is typically uninvolved or shows . Immunohistochemically, angiofibromas demonstrate positivity for in stromal cells, with variable expression of and factor XIIIa, the latter often highlighting stellate fibroblasts. Most cases are negative for S100, smooth muscle , desmin, and cytokeratins, aiding in differentiation from neural or myogenic tumors. Endothelial cells lining the vessels express and . In variants such as cellular angiofibroma, microscopic features include hyalinized thick-walled vessels and focal infiltration by mature adipocytes, with bland spindle cells in a collagenous or myxoid stroma. Juvenile exhibits irregular, staghorn-shaped vascular channels with plump endothelial cells and a fibrous stroma containing stellate fibroblasts. angiofibromas show uniform spindle cells around small branching vessels in a myxoid-collagenous background, often with perivascular hyalinization. Angiofibromas are generally benign neoplasms without a formal grading system, though cellular variants may exhibit mild nuclear in approximately 10-12% of cases, necessitating careful monitoring for rare sarcomatous transformation. Certain subtypes, such as soft tissue angiofibroma, are associated with NCOA2 gene rearrangements, which may briefly inform etiological context.

Types

Cutaneous angiofibromas

Cutaneous angiofibromas are benign dermal tumors composed of fibrovascular tissue, presenting as small, firm papules primarily on the skin of the face, genitals, or periungual regions. They are typically asymptomatic and skin-colored to reddish, measuring a few millimeters in , and occur commonly in adults without causing pain unless subjected to trauma. Key subtypes include fibrous papules, which appear as solitary, dome-shaped lesions, 3-5 mm in size, on the central face such as the or cheeks. represent another subtype, manifesting as multiple, asymptomatic, pearly white papules arranged in rows along the coronal sulcus of the , predominantly in uncircumcised males. Periungual fibromas, also known as Koenen tumors, develop in the nail folds and are strongly associated with complex (TSC), affecting 30-60% of TSC patients. Facial angiofibromas, historically termed , are a hallmark cutaneous feature of TSC, occurring in approximately 75% of affected individuals and often clustering on the cheeks, nose, and chin. These lesions can also appear in isolation or in association with other syndromes like multiple endocrine neoplasia type 1. In , solitary cutaneous angiofibromas may mimic , particularly on the face, necessitating careful clinical distinction based on morphology and history.

Oral and mucosal fibromas

Oral and mucosal fibromas, commonly known as irritation fibromas or focal fibrous hyperplasias, represent a frequent reactive in the oral cavity, accounting for approximately 1-2% of biopsies submitted to oral laboratories. These lesions are more prevalent in individuals over 40 years of age, with a notable occurrence in edentulous patients where chronic from ill-fitting contributes to their development. Gingival variants are also common, comprising a significant portion of reactive gingival enlargements in adults, often linked to local trauma. Clinically, these fibromas typically present as firm, smooth, pedunculated or sessile nodules measuring 1-2 cm in diameter, with a color matching the surrounding mucosa or slightly paler. They most commonly arise on the buccal mucosa along the occlusal line, , , or gingiva due to repeated mechanical from habits like cheek biting, sharp teeth, or prosthetic appliances. The is primarily trauma-induced fibrous , with a less prominent vascular component compared to cutaneous angiofibromas, resulting in a predominantly collagenous stroma. Patients usually experience painless swelling that may interfere with occlusion or speech if large, and the lesions can bleed upon trauma but are otherwise . is exceedingly rare, as these are benign reactive proliferations rather than true neoplasms. Histologically, they exhibit fibrous-vascular tissue with collagen bundles and scattered vessels, confirming their reactive nature.

Juvenile nasopharyngeal angiofibroma

Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign but locally aggressive that predominantly affects adolescent males, with over 90% of cases occurring in individuals aged 10 to 20 years. It arises almost exclusively in males, though rare cases in females and bilateral presentations have been documented. The tumor originates in the , a small space posterior to the , and typically extends into the and due to its expansive growth pattern. Characterized by its highly vascular nature, JNA consists of irregular, thin-walled vessels embedded in a fibrous stroma, which contributes to its propensity for significant bleeding and local . The tumor can erode adjacent structures, such as the walls of the or orbital floor, leading to further extension into surrounding areas like the or in advanced cases. This aggressive local behavior, despite its histological benignity, often necessitates multidisciplinary management to control growth and prevent complications. Clinically, JNA most commonly presents with unilateral epistaxis and nasal obstruction, affecting up to 90% and 60% of patients, respectively, due to the tumor's and vascularity. In early stages, symptoms are subtle, but progression leads to more pronounced issues; the Radkowski staging system classifies disease from stage I (limited to nasopharynx or ) to stage III (extending to or ), with advanced stages (II and III) potentially causing facial asymmetry or deformity from bony remodeling and involvement. Recent insights highlight the role of (VEGF) overexpression in driving the tumor's , with elevated VEGF levels correlating with disease progression and vascular density, particularly in higher stages. This molecular feature underscores the tumor's hypervascularity and supports targeted therapeutic exploration. Etiological theories also implicate expression, potentially linking JNA development to pubertal hormonal changes in affected males.

Soft tissue angiofibromas

Soft tissue angiofibromas, also known as angiofibromas of , represent a rare benign fibroblastic characterized by uniform spindle cells embedded in a collagenous to myxoid stroma intersected by a prominent network of thin-walled, branching vessels forming pseudovascular spaces. First described in 2012, this entity was formally recognized in the 2020 World Health Organization classification of and bone tumors as a distinct within the fibroblastic and myofibroblastic category. These tumors typically arise in the subcutaneous or deeper s, presenting as slow-growing, painless, and mobile subcutaneous nodules measuring 1-4 cm in diameter, though sizes up to 12 cm have been documented. They predominantly occur in the extremities, particularly the lower limbs such as the , region, and distal , often in proximity to joints or fibrotendinous structures, with fewer cases reported in the upper extremities, trunk, or head and neck. Clinically, patients describe these lesions as masses that expand gradually over months to years, lacking changes or inflammatory signs, and they are usually discovered incidentally or due to a palpable lump. Histologically, the tumors feature bland, CD34-positive spindle cells arranged in short fascicles or storiform patterns around the distinctive arborizing vasculature, with low mitotic activity and absence of , contributing to their benign behavior. Over 130 cases have been reported in the as of 2024, underscoring their rarity, with an estimated incidence far below 1 per million population annually. They affect adults primarily in the 40-60 year age range, with a age of 49 years and no significant predilection, though a slight female predominance (approximately 1.4:1) has been noted in compiled series. Complete surgical excision is curative in most instances, with rare local recurrences but no metastatic potential observed. In the differential diagnosis, soft tissue angiofibromas must be distinguished from infiltrative low-grade sarcomas such as dermatofibrosarcoma protuberans, which shares a superficial extremity location and positivity but exhibits more storiform architecture, higher cellularity, and honeycombing fat infiltration without the prominent pseudovascular pattern. Other considerations include solitary fibrous tumor, distinguished by STAT6 expression, and low-grade fibromyxoid sarcoma, which shows alternating fibrous and myxoid areas with MUC4 positivity. , particularly for and EMA (variably positive), along with molecular detection of NCOA2 rearrangements (e.g., AHRR-NCOA2 fusion), aids in confirmation.

Cellular and acral angiofibromas

Cellular angiofibroma is a rare benign mesenchymal characterized by a proliferation of bland spindle cells arranged in short fascicles, accompanied by prominent thin-walled and thick-walled blood vessels, often with a variable adipose component. It predominantly affects the superficial soft tissues of the genital region, with approximately 80% of cases in females occurring in the vulvovaginal area, including the and , while inguinal sites are less common but reported. In females, tumors typically present as well-circumscribed masses measuring 3-5 cm in greatest dimension, though sizes range from 0.6 to 12 cm, and are often painless and slow-growing. Demographically, cellular angiofibroma in women arises in the fourth to sixth decades of life, with a mean age of 46 years and a range of 20-77 years. Molecularly, these tumors exhibit characteristic monoallelic or biallelic loss of the RB1 gene at chromosome 13q14, observed in up to 90% of cases, which contributes to their and distinguishes them from related entities like spindle cell lipoma. Immunohistochemically, tumor cells are positive for , , and often EMA, but negative for S-100, desmin, and CD117 (KIT). Although some cases show nuclear positivity for by , gene is absent, ruling out liposarcoma-like features. Acral angiofibromas represent a distinct variant occurring on the distal extremities, particularly as periungual or subungual fibromas around the nails of toes and fingers. These lesions are small, typically measuring less than 1 cm, and appear as multiple red-brown papules that may cause nail dystrophy, bleeding, or pain. They are frequently associated with tuberous sclerosis complex (TSC), arising in children and adults with the condition, and serve as a major diagnostic criterion when multiple. Histologically, acral angiofibromas feature vascular fibrous tissue with dilated capillaries and bundles, lacking the spindle cell density seen in cellular variants.00258-6/fulltext) Overall, both cellular and acral angiofibromas behave in a benign fashion, with complete surgical excision curative in most instances. Recurrence following excision is uncommon, reported in approximately 2% of cellular angiofibroma cases with follow-up, and even rarer for acral lesions. Rare instances of sarcomatous transformation or atypia occur in cellular angiofibroma (up to 15% of cases), but these do not confer metastatic potential or aggressive behavior.

Clinical presentation

General signs and symptoms

Angiofibromas typically manifest as small to medium-sized, firm nodules or papules that are reddish, pink, or flesh-colored, often occurring singly or in clusters. On dermoscopy, these lesions frequently display telangiectatic vessels or a polymorphous vascular pattern, highlighting their fibrovascular composition. They are generally , though irritation from larger or traumatized lesions can lead to mild discomfort. These benign tumors exhibit slow progression, enlarging gradually over months to years without spontaneous regression. Ulceration or bleeding is uncommon but may occur rarely due to their vascular nature, particularly if the lesion is abraded. Systemic symptoms are typically absent across angiofibroma presentations. The main concern for patients is often cosmetic, especially with visible facial or cutaneous lesions leading to psychological distress or stigmatization. In cases involving oral or nasopharyngeal sites, larger growths can result in functional impairments such as obstruction, though this is not universal. Advanced juvenile nasopharyngeal angiofibroma may additionally cause facial asymmetry due to mass effect.

Presentation by type

Cutaneous angiofibromas typically present as solitary or multiple small, firm papules measuring 1 to 5 mm in diameter, appearing reddish or flesh-colored and commonly located on the face, particularly around the and cheeks, or on the genitals. These lesions are often asymptomatic but may cause cosmetic concerns, and multiple facial forms are frequently associated with tuberous sclerosis complex. In contrast, juvenile nasopharyngeal angiofibromas manifest as a vascular mass in the , leading to unilateral nasal obstruction and recurrent epistaxis, with potential extension causing proptosis, facial deformity, or orbital symptoms if the tumor invades adjacent structures. The Fisch stages these tumors based on extent: stage I is confined to the nasopharynx and ; stage II involves the ; stage III extends to the or ; and stage IV reaches the or pituitary fossa, influencing clinical features like or visual changes in advanced cases. Soft tissue angiofibromas appear as slow-growing, subcutaneous lumps primarily in the extremities, such as the lower legs, measuring several centimeters and remaining painless unless large enough to cause tenderness or pressure effects. These are well-circumscribed and mobile, differing from more superficial cutaneous variants by their deeper location and potential for intermittent pain with growth. Oral and mucosal angiofibromas are rare and present as pedunculated or sessile nodules on the buccal mucosa, gingiva, or , often but prone to growth following trauma or . Periungual and acral angiofibromas, a related subtype, typically occur as small, periungual papules or subcutaneous masses on the fingers, toes, or acral sites, with reddish or skin-colored appearance and enlargement triggered by local trauma, distinguishing them by their distal extremity involvement.

Diagnosis

Clinical evaluation

Clinical evaluation of angiofibroma begins with a detailed history to identify potential risk factors and associated conditions. For cutaneous angiofibromas, the history typically reveals onset during childhood or adolescence, often linked to genetic syndromes such as tuberous sclerosis complex (TSC), multiple endocrine neoplasia type 1 (MEN-1), or Birt-Hogg-Dubé syndrome, necessitating screening for these if multiple facial lesions are present. A family of similar skin lesions or neurological symptoms, such as seizures in TSC, should prompt further evaluation for syndromic associations. In juvenile nasopharyngeal angiofibroma (JNA), history-taking focuses on adolescent males presenting with progressive unilateral nasal obstruction and recurrent, painless epistaxis, with episodes often lasting from months to years before . The duration and frequency of epistaxis, typically unprovoked and intermittent, help differentiate JNA from other nasal pathologies, while inquiring about associated symptoms like facial swelling or aids in assessing tumor extent. Physical examination involves systematic inspection and to characterize lesions. Cutaneous angiofibromas present as small (1-5 mm), firm, dome-shaped papules, often reddish or flesh-colored, clustered on the central face, particularly the and cheeks; confirms their rubbery firmness and lack of tenderness. Dermoscopy enhances suspicion by revealing yellow-white dots and thin, unfocused vessels over a reddish-brown background, distinguishing them from or trichoepithelioma. For oral or mucosal fibromas, intraoral examination identifies pedunculated, firm nodules on the gingiva or buccal mucosa, often asymptomatic unless irritated. For JNA, nasal endoscopy is essential, visualizing a smooth, lobulated, reddish-gray mass in the posterior nasopharynx or , often vascular and non-tender on probing. angiofibromas may appear as subcutaneous nodules on the extremities, palpable as firm, mobile masses without overlying changes. Cellular or acral variants require careful digital examination for tender, periungual papules. Red flags during evaluation include rapid lesion growth or associated pain, which are atypical for benign angiofibromas and may indicate alternative diagnoses such as malignancy or infection, warranting urgent referral.

Imaging and biopsy

Diagnosis of angiofibroma relies on type-specific imaging modalities to confirm clinical suspicion and delineate lesion characteristics, with computed tomography (CT) and magnetic resonance imaging (MRI) being primary tools for juvenile nasopharyngeal angiofibroma (JNA). On CT, JNA typically appears as a vividly enhancing soft-tissue mass centered on the sphenopalatine foramen, often demonstrating bone erosion in the pterygopalatine fossa or surrounding structures. MRI further characterizes JNA as an intensely enhancing lesion with flow voids due to its vascularity, providing superior soft-tissue contrast to assess intracranial extension or involvement of adjacent spaces like the infratemporal fossa. For soft tissue angiofibromas, MRI reveals well-circumscribed, ovoid masses that are iso- to hyperintense on T1-weighted images and hyperintense on T2-weighted sequences, with heterogeneous enhancement post-contrast; ultrasound may aid in initial evaluation of superficial lesions by showing a hypoechoic, vascular mass, though it is less specific. Cutaneous angiofibromas generally do not require routine imaging, as they are diagnosed clinically based on characteristic papular appearance, with ultrasonography reserved for equivocal cases to rule out deeper involvement. Biopsy techniques vary by lesion type and location to balance diagnostic yield with procedural risks. For cutaneous angiofibromas, shave or excisional is preferred, allowing histological confirmation of dilated vessels within a fibrotic stroma, often supplemented by (IHC) panels including (positive in endothelial and dendritic cells) and factor XIIIa (highlighting fibroblastic elements) for accurate differentiation from mimics like . In deep or angiofibromas, core needle is utilized under guidance to obtain adequate tissue for histopathological analysis, revealing a pattern of thin branching vessels amid collagen bundles. However, is contraindicated in suspected vascular JNA prior to preoperative due to the high risk of profuse hemorrhage from its rich arterial supply. Key risks associated with include significant bleeding, particularly in vascular subtypes like JNA, where uncontrolled hemorrhage has been reported even with cautery; in such cases, is achieved via electrocautery or if bleeding occurs. For less vascular cutaneous or lesions, bleeding is typically minor and managed with local pressure or cautery, with overall complication rates low when performed by experienced clinicians.

Management

Nonsurgical treatments

Nonsurgical treatments for angiofibroma primarily target symptom control, lesion reduction, and preoperative optimization, particularly for (JNA) and (TSC)-associated facial lesions. These approaches leverage pharmacological agents to inhibit growth pathways or vascularity, alongside minimally invasive procedures to ablate or devascularize tumors without full excision. For TSC-related facial angiofibromas, topical (rapamycin) inhibits the pathway, leading to substantial lesion improvement. A phase 2 randomized involving 36 patients demonstrated that 0.2% sirolimus gel applied twice daily for 12 weeks reduced tumor volume by 35% overall (29% in children) and improved redness by 5.9 points on a visual analog scale, with the 0.2% concentration identified as optimal for efficacy and safety. Systemic sirolimus may be considered for more extensive or cases, though topical formulations minimize systemic side effects like skin dryness (36%) and irritation (31%). Hormone therapy with flutamide, an anti-androgen, serves as neoadjuvant treatment for JNA by blocking testosterone receptors thought to promote tumor growth. In post-pubertal patients, 6 weeks of flutamide administration prior to achieved at least 25% tumor volume reduction, facilitating easier resection while maintaining safety in small cohorts. This approach is particularly relevant for advanced JNA stages, where it shrinks lesions without significant adverse effects beyond transient liver enzyme elevations. Laser and cryotherapy provide targeted ablation for cutaneous angiofibromas, offering 70-90% clearance in many cases with low scarring risk. (CO2) and neodymium-doped yttrium aluminum garnet (Nd:YAG) lasers effectively vaporize protuberant lesions; a reported 76-100% improvement in 83% of TSC patients after 1-8 sessions spaced 4 weeks apart, excelling at addressing fibrous and erythematous components. , using , yields similar reductions for small lesions in isolated TSC cases, providing an inexpensive, office-based option with minimal downtime despite limited large-scale data. Preoperative embolization devascularizes JNA using particle agents like or , reducing tumor vascularity by 50-70% and intraoperative blood loss accordingly. Performed 24-48 hours before intervention via transarterial routes, this technique penetrates beyond the sphenopalatine region, enhancing safety for Fisch grades II-IVa tumors. As of 2025, topical beta-blockers like 0.5% timolol gel represent emerging advances for small TSC-associated facial angiofibromas, promoting and inhibition. A pediatric study showed significant size and reduction after 3-6 months of nightly application, with excellent tolerability and no systemic absorption concerns, positioning it as a first-line option for superficial lesions.

Surgical and procedural interventions

Surgical interventions for angiofibromas primarily involve excision tailored to the lesion's location and type, aiming for complete removal while minimizing morbidity. For cutaneous and facial angiofibromas, often associated with , shave excision combined with provides symptomatic relief and cosmetic improvement by superficially removing the papules without deep tissue invasion. Similarly, followed by electrodesiccation is employed for small cutaneous or oral lesions, effectively destroying the vascular fibrotic tissue with low recurrence when margins are clear. In juvenile nasopharyngeal angiofibroma (JNA), the most common and vascular subtype, endoscopic endonasal resection is the preferred approach for early-stage lesions (Radkowski stages I-IIb), achieving gross total resection in up to 100% of cases with median blood loss of 175 mL. This minimally invasive technique reduces operative time and hospitalization compared to open methods. For more extensive JNA involving the or (stages III), advanced approaches such as endoscopic-assisted midfacial degloving offer wide exposure for complete tumor clearance, with low recurrence rates in selected cohorts. is standard for angiofibromas, typically involving simple margins for superficial lesions or broader resection for deeper involvement to ensure negative margins and prevent local recurrence, which occurs in about 14% of cases. To minimize recurrence, complete excision with negative margins is recommended for benign angiofibromas, emphasizing complete excision without adjuvant therapies in most instances. Adjuvant radiotherapy is rarely used, particularly in young patients with JNA, due to risks of secondary malignancies, with endoscopic surgery alone sufficient for local control in over 90% of early-stage cases. Preoperative , often performed 24-48 hours prior, reduces vascularity and is a key preparatory step to facilitate safer resection. Complications from angiofibroma surgery are generally low but include intraoperative bleeding, requiring transfusion in approximately 9% of JNA cases, managed through and hemostatic techniques during operation. Other risks, such as leakage in advanced JNA resections, occur in up to 23% but are mitigated by experienced multidisciplinary teams.

Prognosis

Outcomes by type

Cutaneous and oral angiofibromas, when sporadic and not associated with systemic conditions, typically achieve high cure rates following complete surgical excision, with recurrence being minimal due to their benign nature and localized growth. Complete removal is considered curative in most cases, with reported recurrence rates approaching zero when margins are clear. (JNA) post-surgical outcomes show 80-90% of patients achieving disease-free status after endoscopic or open resection, particularly in early stages, though advanced cases require vigilant follow-up. For stage III tumors, regrowth occurs in approximately 20-42% of cases, often linked to residual disease from intracranial extension or incomplete excision. Cellular angiofibroma of exhibits low overall recurrence following complete excision, but incomplete margins elevate the risk significantly, with recurrence being exceedingly rare based on reported cases. Long-term monitoring is essential due to rare sarcomatous transformation, observed in isolated cases with . Angiofibroma of demonstrates rare recurrences after complete surgical excision, with no metastatic potential. Oral and mucosal fibromas, as well as acral angiofibromas, generally exhibit low recurrence rates following complete excision, akin to sporadic cutaneous variants. complex (TSC)-associated facial angiofibromas necessitate chronic management owing to their multifocal and recurrent nature, with topical like demonstrating response rates of 50-60% in reducing lesion size and severity. Maintenance therapy is often required to sustain improvements, as discontinuation frequently leads to lesion reappearance.

Complications and recurrence

Complications of angiofibroma vary by type, with juvenile nasopharyngeal angiofibroma (JNA) carrying the highest risk of intraoperative and postoperative hemorrhage due to its vascular nature and potentially leading to significant blood loss or epistaxis. procedures for JNA may rarely result in vision loss from nontarget or arterial complications, while surgical interventions can cause scarring or facial deformity. For cutaneous angiofibromas, post-excision complications such as scarring and affect about 5% of patients, often linked to or ablative treatments. is exceedingly rare across types, with rates under 1%, typically reported in cellular angiofibromas or post-radiation JNA cases evolving into sarcomas. Recurrence rates for angiofibromas vary widely by type, influenced by incomplete resection, tumor vascularity, and advanced staging. In JNA, recurrences occur in 30-38% of cases, most within 6-36 months post-surgery, particularly with residual disease or high Radkowski stages. Cutaneous angiofibromas show higher recurrence, up to 60-80% after treatments like , due to multifocal growth or syndromic associations. Post-treatment monitoring is essential to detect recurrences early. For JNA, annual or biannual imaging (CT or MRI) is recommended for at least 4-5 years, alongside clinical to differentiate residual tumor from postoperative changes. Cutaneous angiofibromas require regular clinical examinations, focusing on lesion regrowth and skin integrity, without routine imaging. Facial angiofibromas, especially in syndromic contexts like complex, can impair through cosmetic disfigurement, bleeding, or psychosocial distress, often necessitating cosmetic interventions or multidisciplinary care involving and . Effective management, such as topical , has been shown to improve health-related by reducing lesion size and .

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